Cellular immune response to pulmonary infections in HIV-infected individuals hospitalized with diverse grades of immunosuppression

M. J. Miguez-Burbano, D. Ashkin, A. Rodriguez, Robert C. Duncan, M. Flores, B. Acosta, N. Quintero, A. Pitchenik

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

The lymphocyte profile of 521 HIV-infected subjects hospitalized at Jackson Memorial (2001-2002) was compared across main respiratory diseases. Study data included medical history and all laboratory evaluations performed during hospitalization. Community-acquired pneumonias (CAP, 52%), Pneumocystis jiroveci pneumonia (PCP, 24%), tuberculosis (TB, 9%) and non-tuberculous mycobacterial diseases (NTM, 12%) were the most frequent causes of admission. Patients hospitalized with PCP and NTM exhibited the lowest CD4 counts (P=0.003). PCP patients had the highest B-cell percentages (P=0.04). CAP patients had the highest CD8 and CD4 percentages and the lowest percentage of Natural Killer (NK) cells and viral burdens. TB patients exhibited the lowest NK-cell (11.4±6.3) and B-cell percentages (13.6±12) and the highest CD8 (59±14) percentage. NTM patients, in contrast, had the highest NK-cell percentages of the groups (19.1±11.6, P=0.01). Additionally, immune responses associated with respiratory pathogens differed in HIV-infected patients with CD4+ cells above and below 200 counts.

Original languageEnglish (US)
Pages (from-to)271-278
Number of pages8
JournalEpidemiology and Infection
Volume134
Issue number2
DOIs
StatePublished - Apr 1 2006

ASJC Scopus subject areas

  • Epidemiology
  • Infectious Diseases

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