Cellular immune response to pulmonary infections in HIV-infected individuals hospitalized with diverse grades of immunosuppression

M. J. Miguez-Burbano, D. Ashkin, Allan E Rodriguez, R. Duncan, M. Flores, B. Acosta, N. Quintero, A. Pitchenik

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The lymphocyte profile of 521 HIV-infected subjects hospitalized at Jackson Memorial (2001-2002) was compared across main respiratory diseases. Study data included medical history and all laboratory evaluations performed during hospitalization. Community-acquired pneumonias (CAP, 52%), Pneumocystis jiroveci pneumonia (PCP, 24%), tuberculosis (TB, 9%) and non-tuberculous mycobacterial diseases (NTM, 12%) were the most frequent causes of admission. Patients hospitalized with PCP and NTM exhibited the lowest CD4 counts (P=0.003). PCP patients had the highest B-cell percentages (P=0.04). CAP patients had the highest CD8 and CD4 percentages and the lowest percentage of Natural Killer (NK) cells and viral burdens. TB patients exhibited the lowest NK-cell (11.4±6.3) and B-cell percentages (13.6±12) and the highest CD8 (59±14) percentage. NTM patients, in contrast, had the highest NK-cell percentages of the groups (19.1±11.6, P=0.01). Additionally, immune responses associated with respiratory pathogens differed in HIV-infected patients with CD4+ cells above and below 200 counts.

Original languageEnglish
Pages (from-to)271-278
Number of pages8
JournalEpidemiology and Infection
Volume134
Issue number2
DOIs
StatePublished - Apr 1 2006

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Cellular Immunity
Immunosuppression
HIV Infections
Lung
Natural Killer Cells
B-Lymphocytes
HIV
Pneumocystis carinii
Pneumocystis Pneumonia
CD4 Lymphocyte Count
Viral Load
Pneumonia
Tuberculosis
Hospitalization
Lymphocytes

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Cellular immune response to pulmonary infections in HIV-infected individuals hospitalized with diverse grades of immunosuppression. / Miguez-Burbano, M. J.; Ashkin, D.; Rodriguez, Allan E; Duncan, R.; Flores, M.; Acosta, B.; Quintero, N.; Pitchenik, A.

In: Epidemiology and Infection, Vol. 134, No. 2, 01.04.2006, p. 271-278.

Research output: Contribution to journalArticle

Miguez-Burbano, M. J. ; Ashkin, D. ; Rodriguez, Allan E ; Duncan, R. ; Flores, M. ; Acosta, B. ; Quintero, N. ; Pitchenik, A. / Cellular immune response to pulmonary infections in HIV-infected individuals hospitalized with diverse grades of immunosuppression. In: Epidemiology and Infection. 2006 ; Vol. 134, No. 2. pp. 271-278.
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