The macrophage migration inhibition factor assay was used as a specific measure of cellular hypersensitivity to peripheral nervous system antigen in a large group of Guillain Barre patients and control subjects. Lymphocytes from 34 patients with Guillain Barre syndrome, 33 with other peripheral nervous system disease, and 33 normal controls were assayed for production of macrophage migration inhibition factor. A mean of 101 ± 7.2 was obtained in the control group, 70 ± 16.3 in the Guillain Barre syndrome group, and 96 ± 11.3 in those with other peripheral nervous system disease. Twenty six of the 34 patients with Guillain Barre syndrome, two patients with myeloradiculitis, and two with Bell's palsy gave significant values. These results support the hypothesis that cellular hypersensitization to peripheral nervous system antigens is a pathogenetic factor in Guillain Barre syndrome.
ASJC Scopus subject areas
- Clinical Neurology