Cellular hypersensitivity in Guillain Barre syndrome

William Sheremata, R. E. Rocklin, J. David

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The Guillain Barre syndrome is hypothesized to be secondary to cellular hypersensitivity to peripheral nerve antigen. To test this theory lymphocytes from 100 subjects were studied using the macrophage migration inhibition factor (MIF) assay. Thirty four normal controls gave a mean migration of 100.4±9%. Of 34 patients with peripheral nervous system disease, only those with the Guillain Barre syndrome showed hypersensitivity with a mean migration of 72±11%. Of 34 patients with central nervous system disease only 3 with multiple sclerosis and 2 with stroke gave similar results. Positive results in the Guillain Barre syndrome were found only in patients presenting with classical disease and who were ill at the time of study.

Original languageEnglish
Pages (from-to)1245-1247
Number of pages3
JournalCanadian Medical Association Journal
Volume110
Issue number11
StatePublished - Dec 1 1974
Externally publishedYes

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Guillain-Barre Syndrome
Hypersensitivity
Macrophage Migration-Inhibitory Factors
Time and Motion Studies
Central Nervous System Diseases
Peripheral Nervous System Diseases
Peripheral Nerves
Multiple Sclerosis
Stroke
Lymphocytes
Antigens

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Sheremata, W., Rocklin, R. E., & David, J. (1974). Cellular hypersensitivity in Guillain Barre syndrome. Canadian Medical Association Journal, 110(11), 1245-1247.

Cellular hypersensitivity in Guillain Barre syndrome. / Sheremata, William; Rocklin, R. E.; David, J.

In: Canadian Medical Association Journal, Vol. 110, No. 11, 01.12.1974, p. 1245-1247.

Research output: Contribution to journalArticle

Sheremata, W, Rocklin, RE & David, J 1974, 'Cellular hypersensitivity in Guillain Barre syndrome', Canadian Medical Association Journal, vol. 110, no. 11, pp. 1245-1247.
Sheremata W, Rocklin RE, David J. Cellular hypersensitivity in Guillain Barre syndrome. Canadian Medical Association Journal. 1974 Dec 1;110(11):1245-1247.
Sheremata, William ; Rocklin, R. E. ; David, J. / Cellular hypersensitivity in Guillain Barre syndrome. In: Canadian Medical Association Journal. 1974 ; Vol. 110, No. 11. pp. 1245-1247.
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