Cellular hypersensitivity in attacks of multiple sclerosis: I. A comparative study of migration inhibitory factor production and lymphoblastic transformation in response to myelin basic protein in multiple sclerosis

Susan P. Colby, William Sheremata, Barbara Bain, Edwin H. Eylar

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

Although cell mediated hypersensitivity to basic myelin protein has been demonstrated in multiple sclerosis with use of cell migration assays, results with the lymphoblastic transformation technique have been inconclusive. However, prospective studies relating results of lymphoblastic transformation to the clinical course of multiple sclerosis have not been reported. In the present study, both lymphoblastic transformation and migration inhibitory factor assays were used, and results related to the temporal course of multiple sclerosis. Results of the present investigation show that cell mediated hypersensitivity to myelin basic A1 protein is most significant during exacerbations of multiple sclerosis. Responses obtained employing either the lymphoblastic transformation or migration inhibitory factor assay were equally significant. The results support the hypothesis that a factor suppressing deoxyribonucleic acid synthesis is present in multiple sclerosis and is inhibited by the use of steroids.

Original languageEnglish (US)
Pages (from-to)132-139
Number of pages8
JournalNeurology
Volume27
Issue number2
DOIs
StatePublished - Feb 1977

ASJC Scopus subject areas

  • Clinical Neurology

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