Cellular cardiomyoplasty in large myocardial infarction: Can the beneficial effect be enhanced by ACE-inhibitor therapy?

Emerson L. Olivares, Ricardo H. Costa-e-Sousa, João P.S. Werneck-de-Castro, Vanessa Pinho-Ribeiro, Márcia G. Silva, Karla C. Ribeiro, Elisabete C. Mattos, Regina C.S. Goldenberg, Antonio C. Campos de Carvalho, Masako Oya Masuda

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Background: Cellular cardiomyoplasty with bone marrow derived stromal (MSC) and mononuclear (BMNC) cells has been shown to improve performance of infarcted hearts. We performed a comparative study with MSC and BMNC and tested the hypothesis that captopril treatment could enhance the beneficial effect of cell therapy in large myocardial infarctions. Methods: Male syngeneic Wistar rats underwent experimental infarction and were randomized to receive 1-3 × 106 MSC, 108 BMNC or vehicle (BSS group). Two additional groups were treated with captopril and received 1-3 × 106 MSC (Cap.MSC) or vehicle (Cap). Results: The ejection fraction (EF%) of MSC and BMNC-treated rats was higher than in the BSS rats, eight weeks after transplantation (33.0 ± 4.0, 34.0 ± 2.0 and 20.0 ± 2.0% respectively, P < 0.01). Both captopril-treated groups improved EF% similarly. But only captopril plus MSC treatment almost restored cardiac function to control levels, 8 weeks after injection (60.50 ± 5.40% vs. 41.00 ± 4.50% in Cap.MSC and Cap respectively, P < 0.05). Many DAPI-labelled cells were found in the scar tissue of the left ventricle only in the Cap.MSC group. Conclusions: Cell transplantation with both MSC and BMNC produced a similar stabilisation of heart function, but the success of the cell engraftment and the recovery of cardiac performance were dependent on concomitant treatment with captopril.

Original languageEnglish (US)
Pages (from-to)558-567
Number of pages10
JournalEuropean Journal of Heart Failure
Volume9
Issue number6-7
DOIs
StatePublished - Jun 2007
Externally publishedYes

Keywords

  • Captopril
  • Cell therapy
  • Myocardial infarction
  • Stem cells

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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