Abstract
Background: The response to tissue injury requires the symphonious interaction of immune cells, keratinocytes, fibroblasts, and endothelial cells, which unite to regenerate the damaged epithelium. Recent insights have elucidated the cellular and molecular mechanisms required for wound healing and have raised the prospect of novel therapeutic targets. Methods: Review of the pertinent literature. Results: The initial inflammatory response leads to the influx of macrophages and neutrophils, which release cytokines, growth factors, and nitric oxide, and induce nearby keratinocytes to migrate across the wounded epithelium. This process, known as re-epithelialization, requires integrin-mediated activation of Rho-GTPases. The subsequent influx of fibroblasts and endothelial cells results in the production of tissue stroma and formation of new blood vessels, which lead to the generation of functional tissue. Importantly, disease states associated with impaired or excessive wound healing can be attributed to defects in these responses, providing a rationale for the use of evidence-based biological therapies. Conclusion: The elucidation of the cellular and biochemical response to wound healing is essential for an understanding to the treatment of clinical conditions during which impaired healing is encountered.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 23S-35S |
| Journal | Surgical Infections |
| Volume | 3 |
| DOIs | |
| State | Published - Jan 1 2002 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Surgery
- Microbiology (medical)
- Infectious Diseases
Cite this
Cellular, biochemical, and clinical aspects of wound healing. / Hackam, David J.; Ford, Henri.
In: Surgical Infections, Vol. 3, 01.01.2002, p. 23S-35S.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cellular, biochemical, and clinical aspects of wound healing
AU - Hackam, David J.
AU - Ford, Henri
PY - 2002/1/1
Y1 - 2002/1/1
N2 - Background: The response to tissue injury requires the symphonious interaction of immune cells, keratinocytes, fibroblasts, and endothelial cells, which unite to regenerate the damaged epithelium. Recent insights have elucidated the cellular and molecular mechanisms required for wound healing and have raised the prospect of novel therapeutic targets. Methods: Review of the pertinent literature. Results: The initial inflammatory response leads to the influx of macrophages and neutrophils, which release cytokines, growth factors, and nitric oxide, and induce nearby keratinocytes to migrate across the wounded epithelium. This process, known as re-epithelialization, requires integrin-mediated activation of Rho-GTPases. The subsequent influx of fibroblasts and endothelial cells results in the production of tissue stroma and formation of new blood vessels, which lead to the generation of functional tissue. Importantly, disease states associated with impaired or excessive wound healing can be attributed to defects in these responses, providing a rationale for the use of evidence-based biological therapies. Conclusion: The elucidation of the cellular and biochemical response to wound healing is essential for an understanding to the treatment of clinical conditions during which impaired healing is encountered.
AB - Background: The response to tissue injury requires the symphonious interaction of immune cells, keratinocytes, fibroblasts, and endothelial cells, which unite to regenerate the damaged epithelium. Recent insights have elucidated the cellular and molecular mechanisms required for wound healing and have raised the prospect of novel therapeutic targets. Methods: Review of the pertinent literature. Results: The initial inflammatory response leads to the influx of macrophages and neutrophils, which release cytokines, growth factors, and nitric oxide, and induce nearby keratinocytes to migrate across the wounded epithelium. This process, known as re-epithelialization, requires integrin-mediated activation of Rho-GTPases. The subsequent influx of fibroblasts and endothelial cells results in the production of tissue stroma and formation of new blood vessels, which lead to the generation of functional tissue. Importantly, disease states associated with impaired or excessive wound healing can be attributed to defects in these responses, providing a rationale for the use of evidence-based biological therapies. Conclusion: The elucidation of the cellular and biochemical response to wound healing is essential for an understanding to the treatment of clinical conditions during which impaired healing is encountered.
UR - http://www.scopus.com/inward/record.url?scp=85047695297&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85047695297&partnerID=8YFLogxK
U2 - 10.1089/10962960260496316
DO - 10.1089/10962960260496316
M3 - Article
AN - SCOPUS:85047695297
VL - 3
SP - 23S-35S
JO - Surgical Infections
JF - Surgical Infections
SN - 1096-2964
ER -