Cellular and pathophysiological mechanisms of ventricular arrhythmias in acute ischemia and infarction

Frederick A. Ehlert, Jeffrey Goldberger

Research output: Contribution to journalReview article

24 Citations (Scopus)

Abstract

Ventricular arrhythmias in the setting of acute myocardial ischemia and infarction remain a serious health problem because of their sudden and unpredictable nature and their potentially grave results. Electrophysiological changes that may be responsible for these arrhythmias have been described in cardiac cells and in ischemic tissue. Experimental models have played a major role in elucidating the diversity of potential mechanisms for these arrhythmias. Increases in extracellular K+, the presence of toxic metabolites, and the accumulation of catecholamines in ischemic tissue all appear to have a role in arrhythmogenesis. The autonomic nervous system also appears to play a major role in these arrhythmias. With increased understanding of the pathophysiology underlying these arrhythmias, prevention can be enhanced and therapy can be better targeted.

Original languageEnglish (US)
Pages (from-to)966-975
Number of pages10
JournalPACE - Pacing and Clinical Electrophysiology
Volume20
Issue number4 I
DOIs
StatePublished - Jan 1 1997
Externally publishedYes

Fingerprint

Infarction
Cardiac Arrhythmias
Ischemia
Poisons
Autonomic Nervous System
Catecholamines
Myocardial Ischemia
Theoretical Models
Myocardial Infarction
Health
Therapeutics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Cellular and pathophysiological mechanisms of ventricular arrhythmias in acute ischemia and infarction. / Ehlert, Frederick A.; Goldberger, Jeffrey.

In: PACE - Pacing and Clinical Electrophysiology, Vol. 20, No. 4 I, 01.01.1997, p. 966-975.

Research output: Contribution to journalReview article

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