Abstract
Regulation of immune responses to self and foreign antigens is critically dependent on suppressive CD4+ T cells characterized by expression of Foxp3. The large majority of regulatory T (Treg) cells develop in the thymus as a stable suppressive lineage. However, under the proper physiological conditions, conventional peripheral CD4+ T lymphocytes also develop into Treg cells, particularly in the gut mucosa and inflammatory tissue sites. This review will focus on our current understanding of the immunological and molecular signals controlling the development of thymic derived natural (n)Treg and peripheral converted induced (i)Treg cells. Given the importance of Foxp3 in the development of these cells, particular attention is placed on how such signals are integrated to induce and maintain the expression of this signature transcriptional regulator of Treg cells.
| Original language | English |
|---|---|
| Pages (from-to) | 773-782 |
| Number of pages | 10 |
| Journal | Human Immunology |
| Volume | 73 |
| Issue number | 8 |
| DOIs | |
| State | Published - Aug 1 2012 |
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ASJC Scopus subject areas
- Immunology
- Immunology and Allergy
Cite this
Cellular and molecular determinants for the development of natural and induced regulatory T cells. / Yuan, Xiaomei; Malek, Thomas.
In: Human Immunology, Vol. 73, No. 8, 01.08.2012, p. 773-782.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cellular and molecular determinants for the development of natural and induced regulatory T cells
AU - Yuan, Xiaomei
AU - Malek, Thomas
PY - 2012/8/1
Y1 - 2012/8/1
N2 - Regulation of immune responses to self and foreign antigens is critically dependent on suppressive CD4+ T cells characterized by expression of Foxp3. The large majority of regulatory T (Treg) cells develop in the thymus as a stable suppressive lineage. However, under the proper physiological conditions, conventional peripheral CD4+ T lymphocytes also develop into Treg cells, particularly in the gut mucosa and inflammatory tissue sites. This review will focus on our current understanding of the immunological and molecular signals controlling the development of thymic derived natural (n)Treg and peripheral converted induced (i)Treg cells. Given the importance of Foxp3 in the development of these cells, particular attention is placed on how such signals are integrated to induce and maintain the expression of this signature transcriptional regulator of Treg cells.
AB - Regulation of immune responses to self and foreign antigens is critically dependent on suppressive CD4+ T cells characterized by expression of Foxp3. The large majority of regulatory T (Treg) cells develop in the thymus as a stable suppressive lineage. However, under the proper physiological conditions, conventional peripheral CD4+ T lymphocytes also develop into Treg cells, particularly in the gut mucosa and inflammatory tissue sites. This review will focus on our current understanding of the immunological and molecular signals controlling the development of thymic derived natural (n)Treg and peripheral converted induced (i)Treg cells. Given the importance of Foxp3 in the development of these cells, particular attention is placed on how such signals are integrated to induce and maintain the expression of this signature transcriptional regulator of Treg cells.
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UR - http://www.scopus.com/inward/citedby.url?scp=84864047819&partnerID=8YFLogxK
U2 - 10.1016/j.humimm.2012.05.010
DO - 10.1016/j.humimm.2012.05.010
M3 - Article
VL - 73
SP - 773
EP - 782
JO - Human Immunology
JF - Human Immunology
SN - 0198-8859
IS - 8
ER -