Thérapie cellulaire de l'insuffisance sphinctérienne urétrale par autogreffe de cellules précurseur musculaire

Translated title of the contribution: Cell therapy for urethral sphincter incompetence by muscle precursor cell autograft

René Yiou, Laurent Zini, Constant Lecoeur, Jacques Biserte, Claude Abbou, Antony Atala, Dominique Chopin

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations

Abstract

This article reviews cell therapy for muscle diseases and describes the development of a treatment for urethral sphincter insufficiency by muscle precursor cell (MPC) autograft. These studies were conducted in several successive steps, comprising: 1) comparative study of the cellular mechanisms of regeneration of skeletal striated muscle and urethral striated sphincter and development of a method of extraction of MPC; 2) creation of an animal model of sphincter injury reproducing chronic denervation lesions and fibrosis responsible for sphincter insufficiency in human; 3) study of the biology of intrasphincteric transplantation of MPC extracted from peripheral muscle, taking into account the interactions between these cells and the peripheral nervous system.

Translated title of the contributionCell therapy for urethral sphincter incompetence by muscle precursor cell autograft
Original languageFrench
Pages (from-to)93-99
Number of pages7
JournalProgres en Urologie
Volume14
Issue number1
StatePublished - Feb 1 2004

Keywords

  • Cell therapy
  • Regeneration
  • Satellite cell
  • Sphincter insufficiency

ASJC Scopus subject areas

  • Medicine(all)

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