Cell therapy for cystic fibrosis

Sean V. Murphy, Anthony Atala

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Currently there is no cure for cystic fibrosis (CF). Treatments are focused on addressing the disease symptoms, with varying degrees of success. Regenerative medicine holds the promise of regenerating dysfunctional or damaged tissues and to enhance the body's own endogenous repair mechanisms. The discovery of endogenous and exogenous stem cells has provided valuable tools for development of novel treatments for CF. The ability of stem cells to differentiate into functional pulmonary cells, modulate inflammatory responses and contribute to pulmonary function has provided researchers with multiple approaches to develop effective treatment strategies. Several approaches show promise to produce viable therapeutic treatments to treat the underlying cause of CF, reduce the symptoms and mitigate long-term damage, and generate functional replacement organs for end-stage transplantation. This review provides an overview of the rapidly progressing field of cell therapy for CF, focusing on the various cell types utilized and current strategies that show promise to improve life expectancy and quality of life for CF patients.

Original languageEnglish (US)
Pages (from-to)210-223
Number of pages14
JournalJournal of Tissue Engineering and Regenerative Medicine
Volume9
Issue number3
DOIs
StatePublished - Mar 1 2015
Externally publishedYes

Fingerprint

Cell- and Tissue-Based Therapy
Stem cells
Cystic Fibrosis
Repair
Tissue
Stem Cells
Quality of Life
Therapeutics
Lung
Regenerative Medicine
Life Expectancy
Transplantation
Research Personnel

Keywords

  • Animal models
  • Bioengineering
  • Cell therapy
  • Cystic fibrosis
  • Differentiation
  • Disease modelling
  • Inflammation
  • Stem cells

ASJC Scopus subject areas

  • Biomedical Engineering
  • Medicine (miscellaneous)
  • Biomaterials

Cite this

Cell therapy for cystic fibrosis. / Murphy, Sean V.; Atala, Anthony.

In: Journal of Tissue Engineering and Regenerative Medicine, Vol. 9, No. 3, 01.03.2015, p. 210-223.

Research output: Contribution to journalArticle

Murphy, Sean V. ; Atala, Anthony. / Cell therapy for cystic fibrosis. In: Journal of Tissue Engineering and Regenerative Medicine. 2015 ; Vol. 9, No. 3. pp. 210-223.
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