Cell signalling and motile activity.

A. W. Heldman, P. J. Goldschmidt-Clermont

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations


The actin cytoskeleton is a remarkably dynamic structure in non-muscle cells which responds to cell stimulation by a variety of cytokines. A paradigm for such cytokine-induced reorganization of the actin superstructure is the actin response to growth factor of the EGF/PDGF family. This paper reviews the role of the polyphosphoinositide-metabolism, small GTP-binding proteins and profilin in the reorganization of the actin cytoskeleton in cells activated by growth factors.

Original languageEnglish (US)
Pages (from-to)317-324
Number of pages8
JournalSymposia of the Society for Experimental Biology
StatePublished - 1993

ASJC Scopus subject areas

  • Medicine(all)


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