Cell replacement strategies aimed at reconstitution of the β-cell compartment in type 1 diabetes

Giuseppe Orlando, Pierre Gianello, Marcus Salvatori, Robert J. Stratta, Shay Soker, Camillo Ricordi, Juan Dominguez-Bendala

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Emerging technologies in regenerative medicine have the potential to restore the β-cell compartment in diabetic patients, thereby overcoming the inadequacies of current treatment strategies and organ supply. Novel approaches include: 1) Encapsulation technology that protects islet transplants from host immune surveillance; 2) stem cell therapies and cellular reprogramming, which seek to regenerate the depleted β-cell compartment; and 3) whole-organ bioengineering, which capitalizes on the innate properties of the pancreas extracellular matrix to drive cellular repopulation. Collaborative efforts across these subfields of regenerative medicine seek to ultimately produce a bioengineered pancreas capable of restoring endocrine function in patients with insulin-dependent diabetes.

Original languageEnglish
Pages (from-to)1433-1444
Number of pages12
JournalDiabetes
Volume63
Issue number5
DOIs
StatePublished - Jan 1 2014

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Regenerative Medicine
Type 1 Diabetes Mellitus
Pancreas
Technology
Bioengineering
Cell- and Tissue-Based Therapy
Extracellular Matrix
Stem Cells
Insulin
Transplants
Cellular Reprogramming
Therapeutics

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Cell replacement strategies aimed at reconstitution of the β-cell compartment in type 1 diabetes. / Orlando, Giuseppe; Gianello, Pierre; Salvatori, Marcus; Stratta, Robert J.; Soker, Shay; Ricordi, Camillo; Dominguez-Bendala, Juan.

In: Diabetes, Vol. 63, No. 5, 01.01.2014, p. 1433-1444.

Research output: Contribution to journalArticle

Orlando, Giuseppe ; Gianello, Pierre ; Salvatori, Marcus ; Stratta, Robert J. ; Soker, Shay ; Ricordi, Camillo ; Dominguez-Bendala, Juan. / Cell replacement strategies aimed at reconstitution of the β-cell compartment in type 1 diabetes. In: Diabetes. 2014 ; Vol. 63, No. 5. pp. 1433-1444.
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