Cell replacement strategies aimed at reconstitution of the β-cell compartment in type 1 diabetes

Giuseppe Orlando, Pierre Gianello, Marcus Salvatori, Robert J. Stratta, Shay Soker, Camillo Ricordi, Juan Domínguez-Bendala

Research output: Contribution to journalReview article

32 Scopus citations


Emerging technologies in regenerative medicine have the potential to restore the β-cell compartment in diabetic patients, thereby overcoming the inadequacies of current treatment strategies and organ supply. Novel approaches include: 1) Encapsulation technology that protects islet transplants from host immune surveillance; 2) stem cell therapies and cellular reprogramming, which seek to regenerate the depleted β-cell compartment; and 3) whole-organ bioengineering, which capitalizes on the innate properties of the pancreas extracellular matrix to drive cellular repopulation. Collaborative efforts across these subfields of regenerative medicine seek to ultimately produce a bioengineered pancreas capable of restoring endocrine function in patients with insulin-dependent diabetes.

Original languageEnglish (US)
Pages (from-to)1433-1444
Number of pages12
Issue number5
StatePublished - May 2014


ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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