Cell proliferation after laser photocoagulation in primate retina: An autoradiographic study

William E Smiddy, S. L. Fine, H. A. Quigley, G. Dunkelberger, R. M. Hohman, E. M. Addicks

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Argon blue-green laser and krypton red laser (KRL) photocoagulation were applied to primate retinas at intervals ranging from two to 23 days before the animals were killed. An injection of tritiated thymidine was given intravitreally three days before death. Argon blue-green laser photocoagulation induced cell proliferation in the retina and retinal pigment epithelium seven days after treatment, with quiescence at 23 days. Krypton red laser photocoagulation induced similar cell proliferation not only in the retina and retinal pigment epithelium but also around choroidal vessels and in the stroma of the choroid. Peak thymidine uptake occurred seven days after KRL treatment. There was less uptake at two and 11 days and no uptake at 23 days. Thymidine uptake in the retina and choroid also was detected with low levels of KRL treatment. True cell hyperplasia (cell division) occurred after laser treatment; only KRL treatment induced cellular reaction in the choroid.

Original languageEnglish
Pages (from-to)1065-1069
Number of pages5
JournalArchives of Ophthalmology
Volume104
Issue number7
StatePublished - Sep 24 1986
Externally publishedYes

Fingerprint

Light Coagulation
Primates
Krypton
Retina
Lasers
Cell Proliferation
Choroid
Thymidine
Retinal Pigment Epithelium
Argon
Therapeutics
Cell Division
Hyperplasia
Injections

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Smiddy, W. E., Fine, S. L., Quigley, H. A., Dunkelberger, G., Hohman, R. M., & Addicks, E. M. (1986). Cell proliferation after laser photocoagulation in primate retina: An autoradiographic study. Archives of Ophthalmology, 104(7), 1065-1069.

Cell proliferation after laser photocoagulation in primate retina : An autoradiographic study. / Smiddy, William E; Fine, S. L.; Quigley, H. A.; Dunkelberger, G.; Hohman, R. M.; Addicks, E. M.

In: Archives of Ophthalmology, Vol. 104, No. 7, 24.09.1986, p. 1065-1069.

Research output: Contribution to journalArticle

Smiddy, WE, Fine, SL, Quigley, HA, Dunkelberger, G, Hohman, RM & Addicks, EM 1986, 'Cell proliferation after laser photocoagulation in primate retina: An autoradiographic study', Archives of Ophthalmology, vol. 104, no. 7, pp. 1065-1069.
Smiddy WE, Fine SL, Quigley HA, Dunkelberger G, Hohman RM, Addicks EM. Cell proliferation after laser photocoagulation in primate retina: An autoradiographic study. Archives of Ophthalmology. 1986 Sep 24;104(7):1065-1069.
Smiddy, William E ; Fine, S. L. ; Quigley, H. A. ; Dunkelberger, G. ; Hohman, R. M. ; Addicks, E. M. / Cell proliferation after laser photocoagulation in primate retina : An autoradiographic study. In: Archives of Ophthalmology. 1986 ; Vol. 104, No. 7. pp. 1065-1069.
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