Cell-permeable NM23 blocks the maintenance and progression of established pulmonary metastasis

Junghee Lim, Giyong Jang, Seeun Kang, Guewha Lee, Do Thi Thuy Nga, Do Thi Lan Phuong, Hyuncheol Kim, Wael El-Rifai, H. Earl Ruley, Daewoong Jo

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Occult metastases are a major cause of cancer mortality, even among patients undergoing curative resection. Therefore, practical strategies to target the growth and persistence of already established metastases would provide an important advance in cancer treatment. Here, we assessed the potential of protein therapy using a cell permeable NM23-H1 metastasis suppressor protein. Hydrophobic transduction domains developed from a screen of 1,500 signaling peptide sequences enhanced the uptake of the NM23 protein by cultured cells and systemic delivery to animal tissues. The cell-permeable (CP)-NM23 inhibited metastasis-associated phenotypes in tumor cell lines, blocked the establishment of lung metastases, and cleared already established pulmonary metastases, significantly prolonging the survival of tumor-bearing animals. Therefore, these results establish the potential use of cell-permeable metastasis suppressors as adjuvant therapy against disseminated cancers.

Original languageEnglish (US)
Pages (from-to)7216-7225
Number of pages10
JournalCancer Research
Volume71
Issue number23
DOIs
StatePublished - Dec 1 2011
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Lim, J., Jang, G., Kang, S., Lee, G., Nga, D. T. T., Phuong, D. T. L., Kim, H., El-Rifai, W., Ruley, H. E., & Jo, D. (2011). Cell-permeable NM23 blocks the maintenance and progression of established pulmonary metastasis. Cancer Research, 71(23), 7216-7225. https://doi.org/10.1158/0008-5472.CAN-11-2015