Cell-mediated hepatic injury in alcoholic liver disease

Antonio Chedid, Charles L. Mendenhall, Thomas E. Moritz, Samuel W. French, Thomas S. Chen, Timothy R. Morgan, Gary A. Roselle, Bernard A. Nemchausky, Carlo H. Tamburro, Eugene R. Schiff, Craig J. McClain, Luis S. Marsano, John I. Allen, Arun Samanta, Robert E. Weesner, William G. Henderson

Research output: Contribution to journalArticle

90 Scopus citations

Abstract

Background: The mechanism responsible for the initiation and perpetuation of alcoholic liver disease (ALD) remains poorly understood. This investigation attempted to elucidate the role of cell-mediated immune phemonena in the pathogenesis of ethanol-induced liver injury. Methods: Frozen liver biopsy specimens from 144 patients with moderate to severe ALD were examined by the avidin-biotin immunoperoxidase technique for the expression of antigenic markers of T and B lymphocytes, natural killer cells, and class I and II MHC molecules in the tissue. Results: Expression of CDS by lymphocytes correlated significantly with regenerating nodules, intralobular inflammation, central sclerosis, and abnormalities of Kupffer cells. B cells were rarely present, and natural killer cells were absent. CD3+ lymphocytes expressed either CD4 or CD8 surface molecules. Enhanced class I MHC expression correlated significantly with portal inflammation, limiting plate erosion, vascular abnormalities, and hemosiderosis. Expression of class II MHC molecules correlated significantly with necrosis, bile stasis, and Mallory bodies. Conclusions: The distribution and persistence of CD4+ and CD84+ cells in actively advancing ALD, the enhanced MHC expression on hepatocytes, and their relationship to alcoholic hyalin and necrosis lend support to the hypothesis that a cytotoxic T lymphocytehepatocyte interaction plays a role, perhaps via lymphokine production, in the genesis or perpetuation of ALD.

Original languageEnglish (US)
Pages (from-to)254-266
Number of pages13
JournalGastroenterology
Volume105
Issue number1
DOIs
StatePublished - Jul 1993

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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    Chedid, A., Mendenhall, C. L., Moritz, T. E., French, S. W., Chen, T. S., Morgan, T. R., Roselle, G. A., Nemchausky, B. A., Tamburro, C. H., Schiff, E. R., McClain, C. J., Marsano, L. S., Allen, J. I., Samanta, A., Weesner, R. E., & Henderson, W. G. (1993). Cell-mediated hepatic injury in alcoholic liver disease. Gastroenterology, 105(1), 254-266. https://doi.org/10.1016/0016-5085(93)90034-A