Cell cycle related phenothiazine effects on adriamycin transport

Awtar Krishan, Lilly Y.W. Bourguignon

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

In P388 murine leukemic cells, the pheno-thiazine tranquilizer, chlorpromazine, causes a marked increase in intracellular drug retention. Laser excited flow cytometry shows that in log phase cultures this increase in drug retention is not uniform but confined to a sub-population. In cell cycle phase enriched populations of P388 cells obtained by centrifugal elutriation, the phenothiazine enhanced adriamycin retention is seen predominantly in cells in the late S, G2 M part of the cell cycle.

Original languageEnglish (US)
Pages (from-to)449-456
Number of pages8
JournalCell Biology International Reports
Volume8
Issue number6
DOIs
StatePublished - Jun 1984

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ASJC Scopus subject areas

  • Cell Biology

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