Cell-based therapy for prevention and reversal of myocardial remodeling

Vasileios Karantalis, Wayne Balkan, Ivonne H. Schulman, Konstantinos E. Hatzistergos, Joshua M. Hare

Research output: Contribution to journalArticle

61 Scopus citations

Abstract

Although pharmacological and interventional advances have reduced the morbidity and mortality of ischemic heart disease, there is an ongoing need for novel therapeutic strategies that prevent or reverse progressive ventricular remodeling following myocardial infarction, the process that forms the substrate for ventricular failure. The development of cell-based therapy as a strategy to repair or regenerate injured tissue offers extraordinary promise for a powerful anti-remodeling therapy. In this regard, the field of cell therapy has made major advancements in the past decade. Accumulating data from preclinical studies have provided novel insights into stem cell engraftment, differentiation, and interactions with host cellular elements, as well as the effectiveness of various methods of cell delivery and accuracy of diverse imaging modalities to assess therapeutic efficacy. These findings have in turn guided rationally designed translational clinical investigations. Collectively, there is a growing understanding of the parameters that underlie successful cell-based approaches for improving heart structure and function in ischemic and other cardiomyopathies.

Original languageEnglish (US)
Pages (from-to)256-270
Number of pages15
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume303
Issue number3
DOIs
StatePublished - Aug 1 2012

Keywords

  • Bone marrow cells
  • Heart failure
  • Mesenchymal stem cells
  • Myocardial infarction
  • Stem cells

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)
  • Cardiology and Cardiovascular Medicine

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