Cell-based therapy for kidney disease

Hyun Chul Chung, In Kap Ko, Anthony Atala, James J. Yoo

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations

Abstract

The prevalence of renal disease continues to increase worldwide. When normal kidney is injured, the damaged renal tissue undergoes pathological and physiological events that lead to acute and chronic kidney diseases, which frequently progress to end stage renal failure. Current treatment of these renal pathologies includes dialysis, which is incapable of restoring full renal function. To address this issue, cell-based therapy has become a potential therapeutic option to treat renal pathologies. Recent development in cell therapy has demonstrated promising therapeutic outcomes, in terms of restoration of renal structure and function impaired by renal disease. This review focuses on the cell therapy approaches for the treatment of kidney diseases, including various cell sources used, as well recent advances made in preclinical and clinical studies.

Original languageEnglish (US)
Pages (from-to)412-421
Number of pages10
JournalKorean Journal of Urology
Volume56
Issue number6
DOIs
StatePublished - 2015

Keywords

  • Acute kidney injury
  • Cell-and tissue-based therapy
  • Chronic kidney failure
  • Clinical trial
  • Evaluation studies

ASJC Scopus subject areas

  • Urology

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