Cell-based therapies for myocardial repair: Emerging role for bone marrow-derived mesenchymal stem cells (MSCs) in the treatment of the chronically injured heart

Jose S. Da Silva, Joshua Hare

Research output: Chapter in Book/Report/Conference proceedingChapter

19 Scopus citations

Abstract

Accumulating data support the use of bone marrow (BM)-derived MSCs in animal models (e.g., swine) to restore cardiac function and tissue perfusion in chronic cardiac injury. Based on results obtained in swine, we are currently conducting phase I/II clinical trials to address the safety, cell type, cell dose, delivery technique, and efficacy of MSCs in patients with chronic heart failure. MSCs for these trials are isolated from harvested BM and then processed and expanded for intracardiac injection. The BM-MSCs in use for the clinical trials are of clinical grade having been processed successfully in an FDA-approved cGMP facility.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages145-163
Number of pages19
Volume1037
ISBN (Print)9781627035040
DOIs
StatePublished - 2013

Publication series

NameMethods in Molecular Biology
Volume1037
ISSN (Print)10643745

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Keywords

  • BM MSC
  • cGMP
  • cGTP
  • CMC
  • FDA
  • HCT/P
  • HF
  • IND
  • MI

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

Cite this

Da Silva, J. S., & Hare, J. (2013). Cell-based therapies for myocardial repair: Emerging role for bone marrow-derived mesenchymal stem cells (MSCs) in the treatment of the chronically injured heart. In Methods in Molecular Biology (Vol. 1037, pp. 145-163). (Methods in Molecular Biology; Vol. 1037). Humana Press Inc.. https://doi.org/10.1007/978-1-62703-505-7_8