Encapsulated cell technology (ECT) was developed to treat diseases of the central nervous system (CNS) (1–10) and the eye (11). ECT implants consist of living cells encapsulated within a semipermeable polymer membrane and supportive matrices. The encapsulated cells are genetically engineered to produce a specific therapeutic substance to target a specific disease or condition. Once surgically implanted into the CNS or eye, the semipermeable polymer membrane has two main functions: it allows the outward passage of the therapeutic product while protecting the encapsulated cells from rejection by the patient’s immune system. It also permits ready access to oxygen and nutrients (Fig. 1).
|Original language||English (US)|
|Title of host publication||Intraocular Drug Delivery|
|Number of pages||18|
|State||Published - Jan 1 2006|
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