CEACAM1 and the regulation of mucosal inflammation

T. Nagaishi, Zhibin Chen, L. Chen, H. Iijima, A. Nakajima, R. S. Blumberg

Research output: Contribution to journalReview article

16 Scopus citations

Abstract

Inflammatory bowel disease (IBD) is characterized by unrestrained T-cell activation that results in the production of a variety of inflammatory cytokines and other mediators. Understanding the mechanisms of T-cell regulation is therefore of significant importance to IBD and other forms of dysregulated-mucosal inflammation. An area that is of significant interest are the cell autonomous mechanisms of T-cell regulation through proteins that have natural inhibitory functions when expressed on T lymphocytes. One such molecule is carcinoembryonic antigen cell adhesion molecule 1 (CEACAM1). CEACAM1 is primarily an activation-induced cell-surface molecule that functions as a co-inhibitory receptor. Homophilic ligation of CEACAM1 on T cells leads to a signaling mechanism, which results in inhibition of a broad range T-cell functions. CEACAM1 therefore represents a new potential therapeutic target in the treatment of IBD.

Original languageEnglish (US)
Pages (from-to)39-42
Number of pages4
JournalMucosal Immunology
Volume1
DOIs
StatePublished - Jan 1 2008
Externally publishedYes

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ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Nagaishi, T., Chen, Z., Chen, L., Iijima, H., Nakajima, A., & Blumberg, R. S. (2008). CEACAM1 and the regulation of mucosal inflammation. Mucosal Immunology, 1, 39-42. https://doi.org/10.1038/mi.2008.50