Abstract
Inflammatory bowel disease (IBD) is characterized by unrestrained T-cell activation that results in the production of a variety of inflammatory cytokines and other mediators. Understanding the mechanisms of T-cell regulation is therefore of significant importance to IBD and other forms of dysregulated-mucosal inflammation. An area that is of significant interest are the cell autonomous mechanisms of T-cell regulation through proteins that have natural inhibitory functions when expressed on T lymphocytes. One such molecule is carcinoembryonic antigen cell adhesion molecule 1 (CEACAM1). CEACAM1 is primarily an activation-induced cell-surface molecule that functions as a co-inhibitory receptor. Homophilic ligation of CEACAM1 on T cells leads to a signaling mechanism, which results in inhibition of a broad range T-cell functions. CEACAM1 therefore represents a new potential therapeutic target in the treatment of IBD.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 39-42 |
| Number of pages | 4 |
| Journal | Mucosal Immunology |
| Volume | 1 |
| DOIs | |
| State | Published - Jan 1 2008 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Immunology
- Immunology and Allergy
Cite this
CEACAM1 and the regulation of mucosal inflammation. / Nagaishi, T.; Chen, Zhibin; Chen, L.; Iijima, H.; Nakajima, A.; Blumberg, R. S.
In: Mucosal Immunology, Vol. 1, 01.01.2008, p. 39-42.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - CEACAM1 and the regulation of mucosal inflammation
AU - Nagaishi, T.
AU - Chen, Zhibin
AU - Chen, L.
AU - Iijima, H.
AU - Nakajima, A.
AU - Blumberg, R. S.
PY - 2008/1/1
Y1 - 2008/1/1
N2 - Inflammatory bowel disease (IBD) is characterized by unrestrained T-cell activation that results in the production of a variety of inflammatory cytokines and other mediators. Understanding the mechanisms of T-cell regulation is therefore of significant importance to IBD and other forms of dysregulated-mucosal inflammation. An area that is of significant interest are the cell autonomous mechanisms of T-cell regulation through proteins that have natural inhibitory functions when expressed on T lymphocytes. One such molecule is carcinoembryonic antigen cell adhesion molecule 1 (CEACAM1). CEACAM1 is primarily an activation-induced cell-surface molecule that functions as a co-inhibitory receptor. Homophilic ligation of CEACAM1 on T cells leads to a signaling mechanism, which results in inhibition of a broad range T-cell functions. CEACAM1 therefore represents a new potential therapeutic target in the treatment of IBD.
AB - Inflammatory bowel disease (IBD) is characterized by unrestrained T-cell activation that results in the production of a variety of inflammatory cytokines and other mediators. Understanding the mechanisms of T-cell regulation is therefore of significant importance to IBD and other forms of dysregulated-mucosal inflammation. An area that is of significant interest are the cell autonomous mechanisms of T-cell regulation through proteins that have natural inhibitory functions when expressed on T lymphocytes. One such molecule is carcinoembryonic antigen cell adhesion molecule 1 (CEACAM1). CEACAM1 is primarily an activation-induced cell-surface molecule that functions as a co-inhibitory receptor. Homophilic ligation of CEACAM1 on T cells leads to a signaling mechanism, which results in inhibition of a broad range T-cell functions. CEACAM1 therefore represents a new potential therapeutic target in the treatment of IBD.
UR - http://www.scopus.com/inward/record.url?scp=54349124617&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=54349124617&partnerID=8YFLogxK
U2 - 10.1038/mi.2008.50
DO - 10.1038/mi.2008.50
M3 - Review article
C2 - 19079227
AN - SCOPUS:54349124617
VL - 1
SP - 39
EP - 42
JO - Mucosal Immunology
JF - Mucosal Immunology
SN - 1933-0219
ER -