CEACAM1 and the regulation of mucosal inflammation

T. Nagaishi, Zhibin Chen, L. Chen, H. Iijima, A. Nakajima, R. S. Blumberg

Research output: Contribution to journalReview article

15 Citations (Scopus)

Abstract

Inflammatory bowel disease (IBD) is characterized by unrestrained T-cell activation that results in the production of a variety of inflammatory cytokines and other mediators. Understanding the mechanisms of T-cell regulation is therefore of significant importance to IBD and other forms of dysregulated-mucosal inflammation. An area that is of significant interest are the cell autonomous mechanisms of T-cell regulation through proteins that have natural inhibitory functions when expressed on T lymphocytes. One such molecule is carcinoembryonic antigen cell adhesion molecule 1 (CEACAM1). CEACAM1 is primarily an activation-induced cell-surface molecule that functions as a co-inhibitory receptor. Homophilic ligation of CEACAM1 on T cells leads to a signaling mechanism, which results in inhibition of a broad range T-cell functions. CEACAM1 therefore represents a new potential therapeutic target in the treatment of IBD.

Original languageEnglish (US)
Pages (from-to)39-42
Number of pages4
JournalMucosal Immunology
Volume1
DOIs
StatePublished - Jan 1 2008
Externally publishedYes

Fingerprint

Carcinoembryonic Antigen
Cell Adhesion Molecules
Inflammation
T-Lymphocytes
Inflammatory Bowel Diseases
Ligation
Cytokines
Proteins

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Nagaishi, T., Chen, Z., Chen, L., Iijima, H., Nakajima, A., & Blumberg, R. S. (2008). CEACAM1 and the regulation of mucosal inflammation. Mucosal Immunology, 1, 39-42. https://doi.org/10.1038/mi.2008.50

CEACAM1 and the regulation of mucosal inflammation. / Nagaishi, T.; Chen, Zhibin; Chen, L.; Iijima, H.; Nakajima, A.; Blumberg, R. S.

In: Mucosal Immunology, Vol. 1, 01.01.2008, p. 39-42.

Research output: Contribution to journalReview article

Nagaishi, T, Chen, Z, Chen, L, Iijima, H, Nakajima, A & Blumberg, RS 2008, 'CEACAM1 and the regulation of mucosal inflammation', Mucosal Immunology, vol. 1, pp. 39-42. https://doi.org/10.1038/mi.2008.50
Nagaishi T, Chen Z, Chen L, Iijima H, Nakajima A, Blumberg RS. CEACAM1 and the regulation of mucosal inflammation. Mucosal Immunology. 2008 Jan 1;1:39-42. https://doi.org/10.1038/mi.2008.50
Nagaishi, T. ; Chen, Zhibin ; Chen, L. ; Iijima, H. ; Nakajima, A. ; Blumberg, R. S. / CEACAM1 and the regulation of mucosal inflammation. In: Mucosal Immunology. 2008 ; Vol. 1. pp. 39-42.
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