CdSe/ZnS core shell quantum dot-based FRET binary oligonucleotideprobes for detection ofnucleic acids

Yiru Peng, Chunmei Qiu, Steffen Jockusch, Amy M. Scott, Zengmin Li, Nicholas J. Turro, Jingyue Ju

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

We report the design, synthesis, and characterization of a binary oligonucleotideprobe for selective DNA or RNA detection. The probe is based on fluorescence resonance energy transfer (FRET) from quantum dot (CdSe/ZnS core shell) DNA conjugates to organic dye (cyanine-5) DNA conjugates. Selective hybridization of the donor/acceptor DNA conjugates to target DNA enhances FRET and a change in fluorescence signature was observed.

Original languageEnglish (US)
Pages (from-to)881-884
Number of pages4
JournalPhotochemical and Photobiological Sciences
Volume11
Issue number6
DOIs
StatePublished - Jun 1 2012

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ASJC Scopus subject areas

  • Physical and Theoretical Chemistry

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