CdSe/ZnS core shell quantum dot-based FRET binary oligonucleotideprobes for detection ofnucleic acids

Yiru Peng; Chunmei Qiu; Steffen Jockusch; Amy M. Scott; Zengmin Li; Nicholas J. Turro; Jingyue Ju

doi:10.1039/c1pp05132f

CdSe/ZnS core shell quantum dot-based FRET binary oligonucleotideprobes for detection ofnucleic acids

Yiru Peng, Chunmei Qiu, Steffen Jockusch, Amy M. Scott, Zengmin Li, Nicholas J. Turro, Jingyue Ju

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

We report the design, synthesis, and characterization of a binary oligonucleotideprobe for selective DNA or RNA detection. The probe is based on fluorescence resonance energy transfer (FRET) from quantum dot (CdSe/ZnS core shell) DNA conjugates to organic dye (cyanine-5) DNA conjugates. Selective hybridization of the donor/acceptor DNA conjugates to target DNA enhances FRET and a change in fluorescence signature was observed.

Original language	English (US)
Pages (from-to)	881-884
Number of pages	4
Journal	Photochemical and Photobiological Sciences
Volume	11
Issue number	6
DOIs	https://doi.org/10.1039/c1pp05132f
State	Published - Jun 1 2012
Externally published	Yes

ASJC Scopus subject areas

Physical and Theoretical Chemistry

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10.1039/c1pp05132f

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abstract = "We report the design, synthesis, and characterization of a binary oligonucleotideprobe for selective DNA or RNA detection. The probe is based on fluorescence resonance energy transfer (FRET) from quantum dot (CdSe/ZnS core shell) DNA conjugates to organic dye (cyanine-5) DNA conjugates. Selective hybridization of the donor/acceptor DNA conjugates to target DNA enhances FRET and a change in fluorescence signature was observed.",

author = "Yiru Peng and Chunmei Qiu and Steffen Jockusch and Scott, {Amy M.} and Zengmin Li and Turro, {Nicholas J.} and Jingyue Ju",

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AU - Peng, Yiru

AU - Qiu, Chunmei

AU - Jockusch, Steffen

AU - Scott, Amy M.

AU - Li, Zengmin

AU - Turro, Nicholas J.

AU - Ju, Jingyue

PY - 2012/6/1

Y1 - 2012/6/1

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AB - We report the design, synthesis, and characterization of a binary oligonucleotideprobe for selective DNA or RNA detection. The probe is based on fluorescence resonance energy transfer (FRET) from quantum dot (CdSe/ZnS core shell) DNA conjugates to organic dye (cyanine-5) DNA conjugates. Selective hybridization of the donor/acceptor DNA conjugates to target DNA enhances FRET and a change in fluorescence signature was observed.

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