CDKs give Cdc6 a license to drive into S phase

Nagi G. Ayad

doi:10.1016/j.cell.2005.09.001

CDKs give Cdc6 a license to drive into S phase

Nagi G. Ayad

Research output: Contribution to journal › Short survey › peer-review

12 Scopus citations

Abstract

The accumulation of Cdc6 promotes the initiation of DNA replication. In this issue of Cell, Mailand and Diffley (2005) show that phosphorylation of Cdc6 by cyclin-dependent kinases prevents its destruction by the anaphase promoting complex (APC). This simple mechanism explains how the APC simultaneously spares Cdc6 while targeting for destruction suppressors of DNA replication during the transition from quiescence to cell cycle reentry.

Original language	English (US)
Pages (from-to)	825-827
Number of pages	3
Journal	Cell
Volume	122
Issue number	6
DOIs	https://doi.org/10.1016/j.cell.2005.09.001
State	Published - Sep 23 2005
Externally published	Yes

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1016/j.cell.2005.09.001

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abstract = "The accumulation of Cdc6 promotes the initiation of DNA replication. In this issue of Cell, Mailand and Diffley (2005) show that phosphorylation of Cdc6 by cyclin-dependent kinases prevents its destruction by the anaphase promoting complex (APC). This simple mechanism explains how the APC simultaneously spares Cdc6 while targeting for destruction suppressors of DNA replication during the transition from quiescence to cell cycle reentry.",

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AB - The accumulation of Cdc6 promotes the initiation of DNA replication. In this issue of Cell, Mailand and Diffley (2005) show that phosphorylation of Cdc6 by cyclin-dependent kinases prevents its destruction by the anaphase promoting complex (APC). This simple mechanism explains how the APC simultaneously spares Cdc6 while targeting for destruction suppressors of DNA replication during the transition from quiescence to cell cycle reentry.

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