CD99 reactivity in mesenchymal chondrosarcoma

Scott R. Granter, Andrew A. Renshaw, Christopher D M Fletcher, Atul K. Bhan, Andrew Rosenberg

Research output: Contribution to journalArticle

121 Citations (Scopus)

Abstract

CD99 reactivity has been reported to be a sensitive and specific marker for Ewing's sarcoma (ES) and primitive neuroectodermal tumor (PNET). However, within the group of 'small round blue cell tumors,' the specificity has not been extensively examined. We investigated the immunoreactivity of mesenchymal chondrosarcoma to CD99 using the O13 antibody and found reactivity in 11 of 11 (100%) of cases, specifically in the 'small round blue cell' component. All cases showed strong reactivity involving more than 50% of the small round blue cells with a distinct membrane pattern of staining. Staining was either absent or focal and weak in cartilaginous areas. We conclude that mesenchymal chondrosarcoma cannot be distinguished from ES/PNET on the basis of CD99 immunoreactivity.

Original languageEnglish
Pages (from-to)1273-1276
Number of pages4
JournalHuman Pathology
Volume27
Issue number12
DOIs
StatePublished - Dec 21 1996
Externally publishedYes

Fingerprint

Mesenchymal Chondrosarcoma
Primitive Neuroectodermal Tumors
Ewing's Sarcoma
Staining and Labeling
Cellular Structures
Membranes
Antibodies
Neoplasms

Keywords

  • CD99
  • Ewing's sarcoma
  • immunohistochemistry
  • mesenchymal chondrosarcoma
  • MIC2
  • O13
  • primitive neuroectodermal tumors

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Granter, S. R., Renshaw, A. A., Fletcher, C. D. M., Bhan, A. K., & Rosenberg, A. (1996). CD99 reactivity in mesenchymal chondrosarcoma. Human Pathology, 27(12), 1273-1276. https://doi.org/10.1016/S0046-8177(96)90336-6

CD99 reactivity in mesenchymal chondrosarcoma. / Granter, Scott R.; Renshaw, Andrew A.; Fletcher, Christopher D M; Bhan, Atul K.; Rosenberg, Andrew.

In: Human Pathology, Vol. 27, No. 12, 21.12.1996, p. 1273-1276.

Research output: Contribution to journalArticle

Granter, SR, Renshaw, AA, Fletcher, CDM, Bhan, AK & Rosenberg, A 1996, 'CD99 reactivity in mesenchymal chondrosarcoma', Human Pathology, vol. 27, no. 12, pp. 1273-1276. https://doi.org/10.1016/S0046-8177(96)90336-6
Granter SR, Renshaw AA, Fletcher CDM, Bhan AK, Rosenberg A. CD99 reactivity in mesenchymal chondrosarcoma. Human Pathology. 1996 Dec 21;27(12):1273-1276. https://doi.org/10.1016/S0046-8177(96)90336-6
Granter, Scott R. ; Renshaw, Andrew A. ; Fletcher, Christopher D M ; Bhan, Atul K. ; Rosenberg, Andrew. / CD99 reactivity in mesenchymal chondrosarcoma. In: Human Pathology. 1996 ; Vol. 27, No. 12. pp. 1273-1276.
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