CD8+ T cell recognition of cryptic epitopes is a ubiquitous feature of AIDS virus infection

Nicholas J. Maness, Andrew D. Walsh, Shari M. Piaskowski, Jessica Furlott, Holly L. Kolar, Alexander T. Bean, Nancy A. Wilson, David Watkins

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Vaccines designed to elicit AIDS virus-specific CD8+ T cells should engender broad responses. Emerging data indicate that alternate reading frames (ARFs) of both human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) encode CD8+ T cell epitopes, termed cryptic epitopes. Here, we show that SIV-specific CD8+ T cells from SIV-infected rhesus macaques target 14 epitopes in eight ARFs during SIV infection. Animals recognized up to five epitopes, totaling nearly one-quarter of the anti-SIV responses. The epitopes were targeted by high-frequency responses as early as 2 weeks postinfection and in the chronic phase. Hence, previously overlooked ARF-encoded epitopes could be important components of AIDS vaccines.

Original languageEnglish
Pages (from-to)11569-11574
Number of pages6
JournalJournal of Virology
Volume84
Issue number21
DOIs
StatePublished - Nov 1 2010
Externally publishedYes

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Simian Immunodeficiency Virus
Simian immunodeficiency virus
Virus Diseases
epitopes
Epitopes
T-lymphocytes
Reading Frames
HIV
T-Lymphocytes
viruses
infection
AIDS Vaccines
T-Lymphocyte Epitopes
vaccines
Macaca mulatta
Human immunodeficiency virus
Vaccines
animals

ASJC Scopus subject areas

  • Immunology
  • Virology

Cite this

Maness, N. J., Walsh, A. D., Piaskowski, S. M., Furlott, J., Kolar, H. L., Bean, A. T., ... Watkins, D. (2010). CD8+ T cell recognition of cryptic epitopes is a ubiquitous feature of AIDS virus infection. Journal of Virology, 84(21), 11569-11574. https://doi.org/10.1128/JVI.01419-10

CD8+ T cell recognition of cryptic epitopes is a ubiquitous feature of AIDS virus infection. / Maness, Nicholas J.; Walsh, Andrew D.; Piaskowski, Shari M.; Furlott, Jessica; Kolar, Holly L.; Bean, Alexander T.; Wilson, Nancy A.; Watkins, David.

In: Journal of Virology, Vol. 84, No. 21, 01.11.2010, p. 11569-11574.

Research output: Contribution to journalArticle

Maness, NJ, Walsh, AD, Piaskowski, SM, Furlott, J, Kolar, HL, Bean, AT, Wilson, NA & Watkins, D 2010, 'CD8+ T cell recognition of cryptic epitopes is a ubiquitous feature of AIDS virus infection', Journal of Virology, vol. 84, no. 21, pp. 11569-11574. https://doi.org/10.1128/JVI.01419-10
Maness NJ, Walsh AD, Piaskowski SM, Furlott J, Kolar HL, Bean AT et al. CD8+ T cell recognition of cryptic epitopes is a ubiquitous feature of AIDS virus infection. Journal of Virology. 2010 Nov 1;84(21):11569-11574. https://doi.org/10.1128/JVI.01419-10
Maness, Nicholas J. ; Walsh, Andrew D. ; Piaskowski, Shari M. ; Furlott, Jessica ; Kolar, Holly L. ; Bean, Alexander T. ; Wilson, Nancy A. ; Watkins, David. / CD8+ T cell recognition of cryptic epitopes is a ubiquitous feature of AIDS virus infection. In: Journal of Virology. 2010 ; Vol. 84, No. 21. pp. 11569-11574.
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