CD8+ T cell recognition of cryptic epitopes is a ubiquitous feature of AIDS virus infection

Nicholas J. Maness, Andrew D. Walsh, Shari M. Piaskowski, Jessica Furlott, Holly L. Kolar, Alexander T. Bean, Nancy A. Wilson, David I. Watkins

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Vaccines designed to elicit AIDS virus-specific CD8+ T cells should engender broad responses. Emerging data indicate that alternate reading frames (ARFs) of both human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) encode CD8+ T cell epitopes, termed cryptic epitopes. Here, we show that SIV-specific CD8+ T cells from SIV-infected rhesus macaques target 14 epitopes in eight ARFs during SIV infection. Animals recognized up to five epitopes, totaling nearly one-quarter of the anti-SIV responses. The epitopes were targeted by high-frequency responses as early as 2 weeks postinfection and in the chronic phase. Hence, previously overlooked ARF-encoded epitopes could be important components of AIDS vaccines.

Original languageEnglish (US)
Pages (from-to)11569-11574
Number of pages6
JournalJournal of virology
Volume84
Issue number21
DOIs
StatePublished - Nov 2010
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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