CD8+ gamma-delta TCR+ and CD4+ T cells produce IFN-γ at 5-7 days after yellow fever vaccination in Indian rhesus macaques, before the induction of classical antigen-specific T cell responses

Patrícia C.C. Neves, Richard A. Rudersdorf, Ricardo Galler, Myrna C. Bonaldo, Marlon Gilsepp Veloso de Santana, Philip A. Mudd, Maurício A. Martins, Eva G. Rakasz, Nancy A. Wilson, David I. Watkins

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

The yellow fever 17D (YF-17D) vaccine is one of the most efficacious vaccines developed to date. Interestingly, vaccination with YF-17D induces IFN-γ production early after vaccination (days 5-7) before the development of classical antigen-specific CD8+ and CD4+ T cell responses. Here we investigated the cellular source of this early IFN-γ production. At days 5 and 7 post-vaccination activated CD8+ gamma-delta TCR T cells produced IFN-γ and TNF-α. Activated CD4+ T cells produced IFN-γ and TNF-α at day 7 post-vaccination. This early IFN-γ production was also induced after vaccination with recombinant YF-17D (rYF-17D), but was not observed after recombinant Adenovirus type 5 (rAd5) vaccination. Early IFN-γ production, therefore, might be an important aspect of yellow fever vaccination.

Original languageEnglish (US)
Pages (from-to)8183-8188
Number of pages6
JournalVaccine
Volume28
Issue number51
DOIs
StatePublished - Nov 29 2010

Keywords

  • IFN-γ
  • Rhesus model
  • Yellow fever vaccine

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)
  • Molecular Medicine

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