CD8+ gamma-delta TCR+ and CD4+ T cells produce IFN-γ at 5-7 days after yellow fever vaccination in Indian rhesus macaques, before the induction of classical antigen-specific T cell responses

Patrícia C C Neves, Richard A. Rudersdorf, Ricardo Galler, Myrna C. Bonaldo, Marlon Gilsepp Veloso de Santana, Philip A. Mudd, Mauricio Martins, Eva G. Rakasz, Nancy A. Wilson, David Watkins

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

The yellow fever 17D (YF-17D) vaccine is one of the most efficacious vaccines developed to date. Interestingly, vaccination with YF-17D induces IFN-γ production early after vaccination (days 5-7) before the development of classical antigen-specific CD8+ and CD4+ T cell responses. Here we investigated the cellular source of this early IFN-γ production. At days 5 and 7 post-vaccination activated CD8+ gamma-delta TCR T cells produced IFN-γ and TNF-α. Activated CD4+ T cells produced IFN-γ and TNF-α at day 7 post-vaccination. This early IFN-γ production was also induced after vaccination with recombinant YF-17D (rYF-17D), but was not observed after recombinant Adenovirus type 5 (rAd5) vaccination. Early IFN-γ production, therefore, might be an important aspect of yellow fever vaccination.

Original languageEnglish
Pages (from-to)8183-8188
Number of pages6
JournalVaccine
Volume28
Issue number51
DOIs
StatePublished - Nov 29 2010
Externally publishedYes

    Fingerprint

Keywords

  • IFN-γ
  • Rhesus model
  • Yellow fever vaccine

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)
  • Molecular Medicine

Cite this