CD80 (B7.1) and CD54 (Intracellular Adhesion Molecule-1) Induce Target Cell Susceptibility to Promiscuous Cytotoxic T Cell Lysis

Makoto Nishio, Julie Spielman, Richard K. Lee, Debra L. Nelson, Eckhard R. Podack

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Overexpression of B7 and intracellular adhesion molecule-1 (ICAM-1) on syngeneic cells triggered MHC-unrestricted lysis by MHC-restricted CD8+ CTL without TCR/CD3 engagement. Both CD28/B7 and IFA-1/ICAM-1 interactions were required for MHC-nonrestricted cytotoxicity. Cytotoxicity was measured in 4-h and 16- to 18-h cytotoxicity assays. B7-ICAM-1 overexpression triggered perforin- and Fas ligand-mediated lysis, while TNF-α was not elicited in MHC-unrestricted cytotoxicity. These results suggest that target cells may elicit MHC-unrestricted lysis from CTL through up-regulation of membrane adherence and costimulatory receptors.

Original languageEnglish (US)
Pages (from-to)4347-4353
Number of pages7
JournalJournal of Immunology
Volume157
Issue number10
StatePublished - Nov 15 1996

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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