CD8 + T cell escape mutations in simian immunodeficiency virus SIVmac239 cause fitness defects in Vivo, and many revert after transmission

Philip A. Mudd, Adam J. Ericsen, Andrew D. Walsh, Enrique J. León, Nancy A. Wilson, Nicholas J. Maness, Thomas C. Friedrich, David I. Watkins

Research output: Contribution to journalComment/debate

11 Scopus citations

Abstract

Virus-specific CD8 + T lymphocytes select for escape mutations in human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV). To assess the effects of these mutations on viral fitness, we introduced escape mutations into 30 epitopes (bound by five major histocompatibility complex class I [MHC-I] molecules) in three different viruses. Two of these MHC-I alleles are associated with elite control. Two of the three viruses demonstrated reduced fitness in vivo, and 27% of the introduced mutations reverted. These findings suggest that T cell epitope diversity may not be such a daunting problem for the development of an HIV vaccine.

Original languageEnglish (US)
Pages (from-to)12804-12810
Number of pages7
JournalJournal of virology
Volume85
Issue number23
DOIs
StatePublished - Dec 2011

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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