CD8+ Pagetoid Reticulosis Presenting as a Solitary Foot Plaque in a Young Woman

Stephanie J. Martin, Philip R. Cohen, Jeong Hee Cho-Vega, Jaime A. Tschen

Research output: Contribution to journalReview article

6 Scopus citations


Background: Pagetoid reticulosis is a rare variant of mycosis fungoides. This rare condition typically presents as a solitary plaque located on the extremities with an indolent clinical course (Woringer-Kolopp disease) or as a more generalized presentation with diffuse cutaneous involvement and a more aggressive clinical course (Ketron-Goodman disease). Purpose: To review the cutaneous manifestations, pathology, and treatment of localized pagetoid reticulosis. Methods: The authors describe a 24-year-old woman with a slowly enlarging, localized plaque of seven months duration, representing the localized form of pagetoid reticulosis with CD8+ immunophenotype. Results: The histological, immunohistochemical, and clinical features of the patient's skin lesion were characteristic for a diagnosis of Woringer-Kolopp disease. Systemic work-up for lymphoma was negative. Conclusion: Woringer-Kolopp disease is most commonly seen in middle-aged men as a solitary lesion of the extremities, and it should always be considered in the differential diagnosis when a patient presents with such a lesion. A histological analysis demonstrated atypical lymphocytes preferentially localized to the epidermis with a CD4+, CD8+, or CD4-/CD8- phenotype. The treatment of choice for a solitary lesion may be localized radiation therapy, but newer therapies, such as bexarotene, may warrant further investigation.

Original languageEnglish (US)
Number of pages1
JournalJournal of Clinical and Aesthetic Dermatology
Issue number10
StatePublished - Oct 1 2010
Externally publishedYes

ASJC Scopus subject areas

  • Dermatology

Fingerprint Dive into the research topics of 'CD8+ Pagetoid Reticulosis Presenting as a Solitary Foot Plaque in a Young Woman'. Together they form a unique fingerprint.

  • Cite this