Abstract
Background: Pagetoid reticulosis is a rare variant of mycosis fungoides. This rare condition typically presents as a solitary plaque located on the extremities with an indolent clinical course (Woringer-Kolopp disease) or as a more generalized presentation with diffuse cutaneous involvement and a more aggressive clinical course (Ketron-Goodman disease). Purpose: To review the cutaneous manifestations, pathology, and treatment of localized pagetoid reticulosis. Methods: The authors describe a 24-year-old woman with a slowly enlarging, localized plaque of seven months duration, representing the localized form of pagetoid reticulosis with CD8+ immunophenotype. Results: The histological, immunohistochemical, and clinical features of the patient's skin lesion were characteristic for a diagnosis of Woringer-Kolopp disease. Systemic work-up for lymphoma was negative. Conclusion: Woringer-Kolopp disease is most commonly seen in middle-aged men as a solitary lesion of the extremities, and it should always be considered in the differential diagnosis when a patient presents with such a lesion. A histological analysis demonstrated atypical lymphocytes preferentially localized to the epidermis with a CD4+, CD8+, or CD4-/CD8- phenotype. The treatment of choice for a solitary lesion may be localized radiation therapy, but newer therapies, such as bexarotene, may warrant further investigation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 6 |
| Number of pages | 1 |
| Journal | Journal of Clinical and Aesthetic Dermatology |
| Volume | 3 |
| Issue number | 10 |
| State | Published - Oct 2010 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Dermatology
Cite this
CD8+ Pagetoid Reticulosis Presenting as a Solitary Foot Plaque in a Young Woman. / Martin, Stephanie J.; Cohen, Philip R.; Cho, Jeong Hee; Tschen, Jaime A.
In: Journal of Clinical and Aesthetic Dermatology, Vol. 3, No. 10, 10.2010, p. 6.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - CD8+ Pagetoid Reticulosis Presenting as a Solitary Foot Plaque in a Young Woman
AU - Martin, Stephanie J.
AU - Cohen, Philip R.
AU - Cho, Jeong Hee
AU - Tschen, Jaime A.
PY - 2010/10
Y1 - 2010/10
N2 - Background: Pagetoid reticulosis is a rare variant of mycosis fungoides. This rare condition typically presents as a solitary plaque located on the extremities with an indolent clinical course (Woringer-Kolopp disease) or as a more generalized presentation with diffuse cutaneous involvement and a more aggressive clinical course (Ketron-Goodman disease). Purpose: To review the cutaneous manifestations, pathology, and treatment of localized pagetoid reticulosis. Methods: The authors describe a 24-year-old woman with a slowly enlarging, localized plaque of seven months duration, representing the localized form of pagetoid reticulosis with CD8+ immunophenotype. Results: The histological, immunohistochemical, and clinical features of the patient's skin lesion were characteristic for a diagnosis of Woringer-Kolopp disease. Systemic work-up for lymphoma was negative. Conclusion: Woringer-Kolopp disease is most commonly seen in middle-aged men as a solitary lesion of the extremities, and it should always be considered in the differential diagnosis when a patient presents with such a lesion. A histological analysis demonstrated atypical lymphocytes preferentially localized to the epidermis with a CD4+, CD8+, or CD4-/CD8- phenotype. The treatment of choice for a solitary lesion may be localized radiation therapy, but newer therapies, such as bexarotene, may warrant further investigation.
AB - Background: Pagetoid reticulosis is a rare variant of mycosis fungoides. This rare condition typically presents as a solitary plaque located on the extremities with an indolent clinical course (Woringer-Kolopp disease) or as a more generalized presentation with diffuse cutaneous involvement and a more aggressive clinical course (Ketron-Goodman disease). Purpose: To review the cutaneous manifestations, pathology, and treatment of localized pagetoid reticulosis. Methods: The authors describe a 24-year-old woman with a slowly enlarging, localized plaque of seven months duration, representing the localized form of pagetoid reticulosis with CD8+ immunophenotype. Results: The histological, immunohistochemical, and clinical features of the patient's skin lesion were characteristic for a diagnosis of Woringer-Kolopp disease. Systemic work-up for lymphoma was negative. Conclusion: Woringer-Kolopp disease is most commonly seen in middle-aged men as a solitary lesion of the extremities, and it should always be considered in the differential diagnosis when a patient presents with such a lesion. A histological analysis demonstrated atypical lymphocytes preferentially localized to the epidermis with a CD4+, CD8+, or CD4-/CD8- phenotype. The treatment of choice for a solitary lesion may be localized radiation therapy, but newer therapies, such as bexarotene, may warrant further investigation.
UR - http://www.scopus.com/inward/record.url?scp=78149240558&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78149240558&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:78149240558
VL - 3
SP - 6
JO - Journal of Clinical and Aesthetic Dermatology
JF - Journal of Clinical and Aesthetic Dermatology
SN - 1941-2789
IS - 10
ER -