CD8+ Pagetoid Reticulosis Presenting as a Solitary Foot Plaque in a Young Woman

Stephanie J. Martin, Philip R. Cohen, Jeong Hee Cho, Jaime A. Tschen

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: Pagetoid reticulosis is a rare variant of mycosis fungoides. This rare condition typically presents as a solitary plaque located on the extremities with an indolent clinical course (Woringer-Kolopp disease) or as a more generalized presentation with diffuse cutaneous involvement and a more aggressive clinical course (Ketron-Goodman disease). Purpose: To review the cutaneous manifestations, pathology, and treatment of localized pagetoid reticulosis. Methods: The authors describe a 24-year-old woman with a slowly enlarging, localized plaque of seven months duration, representing the localized form of pagetoid reticulosis with CD8+ immunophenotype. Results: The histological, immunohistochemical, and clinical features of the patient's skin lesion were characteristic for a diagnosis of Woringer-Kolopp disease. Systemic work-up for lymphoma was negative. Conclusion: Woringer-Kolopp disease is most commonly seen in middle-aged men as a solitary lesion of the extremities, and it should always be considered in the differential diagnosis when a patient presents with such a lesion. A histological analysis demonstrated atypical lymphocytes preferentially localized to the epidermis with a CD4+, CD8+, or CD4-/CD8- phenotype. The treatment of choice for a solitary lesion may be localized radiation therapy, but newer therapies, such as bexarotene, may warrant further investigation.

Original languageEnglish (US)
Pages (from-to)6
Number of pages1
JournalJournal of Clinical and Aesthetic Dermatology
Volume3
Issue number10
StatePublished - Oct 2010
Externally publishedYes

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Pagetoid Reticulosis
Foot
Extremities
Skin Manifestations
Mycosis Fungoides
Skin
Epidermis
Lymphoma
Differential Diagnosis
Radiotherapy
Therapeutics
Lymphocytes
Pathology
Phenotype

ASJC Scopus subject areas

  • Dermatology

Cite this

CD8+ Pagetoid Reticulosis Presenting as a Solitary Foot Plaque in a Young Woman. / Martin, Stephanie J.; Cohen, Philip R.; Cho, Jeong Hee; Tschen, Jaime A.

In: Journal of Clinical and Aesthetic Dermatology, Vol. 3, No. 10, 10.2010, p. 6.

Research output: Contribution to journalArticle

Martin, Stephanie J. ; Cohen, Philip R. ; Cho, Jeong Hee ; Tschen, Jaime A. / CD8+ Pagetoid Reticulosis Presenting as a Solitary Foot Plaque in a Young Woman. In: Journal of Clinical and Aesthetic Dermatology. 2010 ; Vol. 3, No. 10. pp. 6.
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