CD5 negative, cyclin D1-positive diffuse large B-cell lymphoma (DLBCL) presenting as ruptured spleen

Julie Teruya-Feldstein, Anuradha Gopalan, Craig H. Moskowitz

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

We present a case of diffuse large B-cell lymphoma CD5 negative, Cyclin D1 positive presenting as ruptured spleen in a 63-year-old man requiring emergent splenectomy. Tumor cells showed marked pleomorphism, anaplasia, and increased mitotic figures with positive Cyclin D1, BCL6, MUM1, P53, and a high MIB1 proliferative fraction. The patient received multiple therapies and ultimately died. This case raises the differential diagnoses of pleomorphic mantle cell lymphoma and other aggressive lymphomas with pleomorphic, anaplastic, and Reed-Sternberg-like cells.

Original languageEnglish (US)
Pages (from-to)255-258
Number of pages4
JournalApplied Immunohistochemistry and Molecular Morphology
Volume17
Issue number3
DOIs
StatePublished - May 1 2009
Externally publishedYes

Keywords

  • CD5 negative
  • Cyclin D1-positive DLBCL
  • Pleomorphic mantle cell lymphoma
  • Splenic rupture

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Medical Laboratory Technology

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