Abstract
Lethal autoimmunity associated with IL-2Rβ-deficient mice is prevented after thymic transgenic expression of wild-type IL-2Rβ in IL-2Rβ-/- mice (Tg -/- mice). Here, we show that CD4+CD25+ regulatory T cells were not readily detected in IL-2Rβ-/- mice, but the production of functional CD4+CD25+ T cells was reconstituted in Tg -/- mice. Adoptive transfer of normal CD4+CD25+ T cells into neonatal IL-2Rβ-deficient mice prevented this lethal autoimmune syndrome. The CD4+CD25+ T cells in disease-free adult IL-2Rβ-deficient recipient mice were present at a near normal frequency, were solely donor-derived, and depended on IL-2 for expansion. These observations indicate that the essential function of the IL-2/IL-2R system primarily lies at the level of the production of CD4+CD25+ regulatory T cells.
| Original language | English |
|---|---|
| Pages (from-to) | 167-178 |
| Number of pages | 12 |
| Journal | Immunity |
| Volume | 17 |
| Issue number | 2 |
| DOIs | |
| State | Published - Aug 1 2002 |
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ASJC Scopus subject areas
- Immunology and Allergy
- Infectious Diseases
- Immunology
Cite this
CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rβ-deficient mice : Implications for the nonredundant function of IL-2. / Malek, Thomas; Yu, Aixin; Vincek, Vladimir; Scibelli, Paul; Kong, Lin.
In: Immunity, Vol. 17, No. 2, 01.08.2002, p. 167-178.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rβ-deficient mice
T2 - Implications for the nonredundant function of IL-2
AU - Malek, Thomas
AU - Yu, Aixin
AU - Vincek, Vladimir
AU - Scibelli, Paul
AU - Kong, Lin
PY - 2002/8/1
Y1 - 2002/8/1
N2 - Lethal autoimmunity associated with IL-2Rβ-deficient mice is prevented after thymic transgenic expression of wild-type IL-2Rβ in IL-2Rβ-/- mice (Tg -/- mice). Here, we show that CD4+CD25+ regulatory T cells were not readily detected in IL-2Rβ-/- mice, but the production of functional CD4+CD25+ T cells was reconstituted in Tg -/- mice. Adoptive transfer of normal CD4+CD25+ T cells into neonatal IL-2Rβ-deficient mice prevented this lethal autoimmune syndrome. The CD4+CD25+ T cells in disease-free adult IL-2Rβ-deficient recipient mice were present at a near normal frequency, were solely donor-derived, and depended on IL-2 for expansion. These observations indicate that the essential function of the IL-2/IL-2R system primarily lies at the level of the production of CD4+CD25+ regulatory T cells.
AB - Lethal autoimmunity associated with IL-2Rβ-deficient mice is prevented after thymic transgenic expression of wild-type IL-2Rβ in IL-2Rβ-/- mice (Tg -/- mice). Here, we show that CD4+CD25+ regulatory T cells were not readily detected in IL-2Rβ-/- mice, but the production of functional CD4+CD25+ T cells was reconstituted in Tg -/- mice. Adoptive transfer of normal CD4+CD25+ T cells into neonatal IL-2Rβ-deficient mice prevented this lethal autoimmune syndrome. The CD4+CD25+ T cells in disease-free adult IL-2Rβ-deficient recipient mice were present at a near normal frequency, were solely donor-derived, and depended on IL-2 for expansion. These observations indicate that the essential function of the IL-2/IL-2R system primarily lies at the level of the production of CD4+CD25+ regulatory T cells.
UR - http://www.scopus.com/inward/record.url?scp=0036669298&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036669298&partnerID=8YFLogxK
U2 - 10.1016/S1074-7613(02)00367-9
DO - 10.1016/S1074-7613(02)00367-9
M3 - Article
C2 - 12196288
AN - SCOPUS:0036669298
VL - 17
SP - 167
EP - 178
JO - Immunity
JF - Immunity
SN - 1074-7613
IS - 2
ER -