CD4 intragenic SNPs associate with HIV-2 plasma viral load and CD4 count in a community-based study from guinea-bissau, West Africa

Branwen J. Hennig, Digna R. Velez-Edwards, Maarten F. Schim Van Der Loeff, Cyrille Bisseye, Todd L. Edwards, Alessandra Tacconelli, Giuseppe Novelli, Peter Aaby, Steve Kaye, William K Scott, Assan Jaye, Hilton C. Whittle, Scott M. Williams, Adrian V. Hill, Giorgio Sirugo

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objectives: The human genetics of HIV-2 infection and disease progression is understudied. Therefore, we studied the effect of variation in 2 genes that encode products critical to HIV pathogenesis and disease progression: CD4 and CD209. Design: This cross-sectional study consisted of 143 HIV-2, 30 HIV-1 + HIV-2 and 29 HIV-1-infected subjects and 194 uninfected controls recruited from rural Guinea-Bissau. Methods: We genotyped 14 CD4 and 4 CD209 single nucleotide polymorphisms (SNPs) that were tested for association with HIV infection, HIV-2 plasma viral load (high vs. low), and CD4 T-cell count (high vs. low). Results: The most significant association was between a CD4 haplotype rs11575097-rs10849523 and high viral load [odds ratio (OR): = 2.37, 95% confidence interval (CI): 1.35 to 4.19, P = 0.001, corrected for multiple testing], suggesting increased genetic susceptibility to HIV-2 disease progression for individuals carrying the high-risk haplotype. Significant associations were also observed at a CD4 SNP (rs2255301) with HIV-2 infection (OR: = 2.36, 95% CI: 1.19 to 4.65, P = 0.01) and any HIV infection (OR: = 2.50, 95% CI: 1.34 to 4.69, P = 0.004). Conclusions: Our results support a role of CD4 polymorphisms in HIV-2 infection, in agreement with recent data showing that CD4 gene variants increase risk to HIV-1 in Kenyan female sex workers. These findings indicate at least some commonality in HIV-1 and HIV-2 susceptibility.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalJournal of Acquired Immune Deficiency Syndromes
Volume56
Issue number1
DOIs
StatePublished - Jan 1 2011
Externally publishedYes

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Guinea-Bissau
HIV-2
Western Africa
CD4 Lymphocyte Count
Viral Load
Single Nucleotide Polymorphism
HIV Infections
HIV-1
Disease Progression
Odds Ratio
Confidence Intervals
Haplotypes
Sex Workers
Medical Genetics
Genetic Predisposition to Disease
Genes
Cross-Sectional Studies
HIV
T-Lymphocytes

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

Cite this

Hennig, B. J., Velez-Edwards, D. R., Schim Van Der Loeff, M. F., Bisseye, C., Edwards, T. L., Tacconelli, A., ... Sirugo, G. (2011). CD4 intragenic SNPs associate with HIV-2 plasma viral load and CD4 count in a community-based study from guinea-bissau, West Africa. Journal of Acquired Immune Deficiency Syndromes, 56(1), 1-8. https://doi.org/10.1097/QAI.0b013e3181f638ed

CD4 intragenic SNPs associate with HIV-2 plasma viral load and CD4 count in a community-based study from guinea-bissau, West Africa. / Hennig, Branwen J.; Velez-Edwards, Digna R.; Schim Van Der Loeff, Maarten F.; Bisseye, Cyrille; Edwards, Todd L.; Tacconelli, Alessandra; Novelli, Giuseppe; Aaby, Peter; Kaye, Steve; Scott, William K; Jaye, Assan; Whittle, Hilton C.; Williams, Scott M.; Hill, Adrian V.; Sirugo, Giorgio.

In: Journal of Acquired Immune Deficiency Syndromes, Vol. 56, No. 1, 01.01.2011, p. 1-8.

Research output: Contribution to journalArticle

Hennig, BJ, Velez-Edwards, DR, Schim Van Der Loeff, MF, Bisseye, C, Edwards, TL, Tacconelli, A, Novelli, G, Aaby, P, Kaye, S, Scott, WK, Jaye, A, Whittle, HC, Williams, SM, Hill, AV & Sirugo, G 2011, 'CD4 intragenic SNPs associate with HIV-2 plasma viral load and CD4 count in a community-based study from guinea-bissau, West Africa', Journal of Acquired Immune Deficiency Syndromes, vol. 56, no. 1, pp. 1-8. https://doi.org/10.1097/QAI.0b013e3181f638ed
Hennig, Branwen J. ; Velez-Edwards, Digna R. ; Schim Van Der Loeff, Maarten F. ; Bisseye, Cyrille ; Edwards, Todd L. ; Tacconelli, Alessandra ; Novelli, Giuseppe ; Aaby, Peter ; Kaye, Steve ; Scott, William K ; Jaye, Assan ; Whittle, Hilton C. ; Williams, Scott M. ; Hill, Adrian V. ; Sirugo, Giorgio. / CD4 intragenic SNPs associate with HIV-2 plasma viral load and CD4 count in a community-based study from guinea-bissau, West Africa. In: Journal of Acquired Immune Deficiency Syndromes. 2011 ; Vol. 56, No. 1. pp. 1-8.
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