CD4 downregulation by memory CD4+ T cells in vivo renders African green monkeys resistant to progressive SIVagm infection

Coreen M. Beaumier, Levelle D. Harris, Simoy Goldstein, Nichole Klatt, Sonya Whitted, John McGinty, Cristian Apetrei, Ivona Pandrea, Vanessa M. Hirsch, Jason M. Brenchley

Research output: Contribution to journalArticle

96 Citations (Scopus)

Abstract

African green monkeys (genus Chlorocebus) can be infected with species-specific simian immunodeficiency virus (SIVagm) but do not develop AIDS. These natural hosts of SIV, like sooty mangabeys, maintain high levels of SIV replication but have evolved to avoid immunodeficiency. Elucidating the mechanisms that allow natural hosts to coexist with SIV without overt disease may provide crucial information for understanding AIDS pathogenesis. Here we show that many CD4+ T cells from African green monkeys downregulate CD4 in vivo as they enter the memory pool; that downregulation of CD4 by memory T cells is independent of SIV infection; that the CD4 memory T cells maintain functions that are normally attributed to CD4+ T cells, including production of interleukin-2 (IL-2), production of IL-17, expression of forkhead box P3 and expression of CD40 ligand; that loss of CD4 expression protects these T cells from infection by SIVagm in vivo; and that these CD 4 T cells can maintain major histocompatibility complex class II restriction. These data show that the absence of SIV-induced disease progression in natural host species may be partially explained by preservation of a subset of T cells that maintain CD4+ T cell function while being resistant to SIV infection in vivo.

Original languageEnglish (US)
Pages (from-to)879-885
Number of pages7
JournalNature Medicine
Volume15
Issue number8
DOIs
StatePublished - Aug 1 2009
Externally publishedYes

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Cercopithecus aethiops
T-cells
Down-Regulation
T-Lymphocytes
Data storage equipment
Infection
Cercocebus atys
Acquired Immunodeficiency Syndrome
Simian Immunodeficiency Virus
CD40 Ligand
Interleukin-17
T-Lymphocyte Subsets
Major Histocompatibility Complex
Interleukin-2
Disease Progression
Viruses

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Beaumier, C. M., Harris, L. D., Goldstein, S., Klatt, N., Whitted, S., McGinty, J., ... Brenchley, J. M. (2009). CD4 downregulation by memory CD4+ T cells in vivo renders African green monkeys resistant to progressive SIVagm infection. Nature Medicine, 15(8), 879-885. https://doi.org/10.1038/nm.1970

CD4 downregulation by memory CD4+ T cells in vivo renders African green monkeys resistant to progressive SIVagm infection. / Beaumier, Coreen M.; Harris, Levelle D.; Goldstein, Simoy; Klatt, Nichole; Whitted, Sonya; McGinty, John; Apetrei, Cristian; Pandrea, Ivona; Hirsch, Vanessa M.; Brenchley, Jason M.

In: Nature Medicine, Vol. 15, No. 8, 01.08.2009, p. 879-885.

Research output: Contribution to journalArticle

Beaumier, CM, Harris, LD, Goldstein, S, Klatt, N, Whitted, S, McGinty, J, Apetrei, C, Pandrea, I, Hirsch, VM & Brenchley, JM 2009, 'CD4 downregulation by memory CD4+ T cells in vivo renders African green monkeys resistant to progressive SIVagm infection', Nature Medicine, vol. 15, no. 8, pp. 879-885. https://doi.org/10.1038/nm.1970
Beaumier, Coreen M. ; Harris, Levelle D. ; Goldstein, Simoy ; Klatt, Nichole ; Whitted, Sonya ; McGinty, John ; Apetrei, Cristian ; Pandrea, Ivona ; Hirsch, Vanessa M. ; Brenchley, Jason M. / CD4 downregulation by memory CD4+ T cells in vivo renders African green monkeys resistant to progressive SIVagm infection. In: Nature Medicine. 2009 ; Vol. 15, No. 8. pp. 879-885.
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