CD38+CD8+ T-cells negatively correlate with CD4 central memory cells in virally suppressed HIV-1-infected individuals

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Objective: Studies have found that CD8 T-cell activation, as measured by CD38 expression, in HI V-1-infected individuals on suppressive therapy for longer than 12 months is not predictive of CD4 T-cell recovery. Owing to the fact that reconstitution of memory and naive T-cell populations occurs differentially over time, this study evaluated whether distinct memory/naive CD4 T-cell subsets correlated with CD38 on CD8 T-cells. Materials and Methods: Whole blood from 13 participants was used to evaluate activation phenotypic markers on CD8 lymphocytes and memory/naive phenotypes on CD4 lymphocytes. These HIV-1 -infected individuals had stable CD4 cell counts for more than 1 year while on suppressive combination antiretroviral therapy. Results: The results demonstrate that CD4 central memory and naive cell populations contribute to the magnitude of CD4 T-cell reconstitution. CD4 central memory has a significant negative correlation with the percentage of CD38-activated CD8 T-cells. Conclusion: This suggests that CD8 activation is important in CD4 recovery from a low CD4 T-cell nadir.

Original languageEnglish (US)
Pages (from-to)1937-1941
Number of pages5
JournalAIDS
Volume22
Issue number15
StatePublished - Jan 1 2008

Keywords

  • CD38
  • Cell activation
  • HIV/AIDS
  • Memory cells
  • Naïve cells

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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