Abstract
Objective: Studies have found that CD8 T-cell activation, as measured by CD38 expression, in HI V-1-infected individuals on suppressive therapy for longer than 12 months is not predictive of CD4 T-cell recovery. Owing to the fact that reconstitution of memory and naive T-cell populations occurs differentially over time, this study evaluated whether distinct memory/naive CD4 T-cell subsets correlated with CD38 on CD8 T-cells. Materials and Methods: Whole blood from 13 participants was used to evaluate activation phenotypic markers on CD8 lymphocytes and memory/naive phenotypes on CD4 lymphocytes. These HIV-1 -infected individuals had stable CD4 cell counts for more than 1 year while on suppressive combination antiretroviral therapy. Results: The results demonstrate that CD4 central memory and naive cell populations contribute to the magnitude of CD4 T-cell reconstitution. CD4 central memory has a significant negative correlation with the percentage of CD38-activated CD8 T-cells. Conclusion: This suggests that CD8 activation is important in CD4 recovery from a low CD4 T-cell nadir.
Original language | English (US) |
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Pages (from-to) | 1937-1941 |
Number of pages | 5 |
Journal | AIDS |
Volume | 22 |
Issue number | 15 |
State | Published - Jan 1 2008 |
Keywords
- CD38
- Cell activation
- HIV/AIDS
- Memory cells
- Naïve cells
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Infectious Diseases