CD30L/CD30 is critical for maintenance of IL-17A-producing γδ T cells bearing Vγ6 in mucosa-associated tissues in mice

X. Sun, K. Shibata, H. Yamada, Y. Guo, H. Muta, E. R. Podack, Y. Yoshikai

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

CD30 ligand (CD30L, CD153), a member of the tumor necrosis factor (TNF) superfamily, and its receptor CD30 are important for differentiation and activation of CD4 + T helper type 17 (Th17) cells. In this report, we demonstrate that the interleukin 17A (IL-17A)-producing γδ T cells normally developed in the fetal thymus, whereas Vγ1 - Vγ4 - γδ T cells expressed Vγ6/Vδ1 gene transcript selectively decreased in mucosa-associated tissues in naive CD30KO or CD30LKO mice. Moreover, CD30 and CD30L were expressed preferentially by Vγ1 - Vγ4 - γδ T cells in naive mice. The bacteria clearance was attenuated by the impaired response of the IL-17A-producing γδ T cells and decreased infiltration of neutrophils in CD30KO or CD30LKO mice. In vivo administration of agonistic anti-CD30 monoclonal antibody restored the ability of protection against Listeria monocytogenes by enhancing Vγ1 - Vγ4 - γδ T cells producing IL-17A not only in wild-type but also CD30LKO mice. Taken together, it appears that CD30L/CD30 signaling plays an important role in the maintenance and activation of IL-17A-producing γδ T cells presumably bearing Vγ6 in the mucosa-associated tissues of mice.

Original languageEnglish
Pages (from-to)1191-1201
Number of pages11
JournalMucosal Immunology
Volume6
Issue number6
DOIs
StatePublished - Nov 1 2013
Externally publishedYes

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Interleukin-17
Mucous Membrane
Maintenance
T-Lymphocytes
CD30 Ligand
Th17 Cells
Neutrophil Infiltration
Listeria monocytogenes
Thymus Gland
Tumor Necrosis Factor-alpha
Monoclonal Antibodies
Bacteria
Genes

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

CD30L/CD30 is critical for maintenance of IL-17A-producing γδ T cells bearing Vγ6 in mucosa-associated tissues in mice. / Sun, X.; Shibata, K.; Yamada, H.; Guo, Y.; Muta, H.; Podack, E. R.; Yoshikai, Y.

In: Mucosal Immunology, Vol. 6, No. 6, 01.11.2013, p. 1191-1201.

Research output: Contribution to journalArticle

Sun, X. ; Shibata, K. ; Yamada, H. ; Guo, Y. ; Muta, H. ; Podack, E. R. ; Yoshikai, Y. / CD30L/CD30 is critical for maintenance of IL-17A-producing γδ T cells bearing Vγ6 in mucosa-associated tissues in mice. In: Mucosal Immunology. 2013 ; Vol. 6, No. 6. pp. 1191-1201.
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