CD10 and Bcl10 expression in diffuse large B-cell lymphoma: CD10 is a marker of improved prognosis

K. Ohshima, C. Kawasaki, H. Muta, K. Muta, V. Deyev, S. Haraoka, J. Suzumiya, E. R. Podack, M. Kikuchi

Research output: Contribution to journalArticle

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Abstract

Aims: Diffuse large B-cell lymphoma (DLBCL), the most common subtype of non-Hodgkin's lymphoma, is clinically and pathologically heterogeneous. The Bcl10 gene was recently isolated from the breakpoint region of t(1;14)(p22;q32) in mucosa-associated lymphoid tissue (MALT) lymphomas, and is considered to be an apoptosis-associated gene. CD10 is considered to be a marker of follicular centre B-cell differentiation. To assess the clinical significance and roles of CD10 and Bcl10 in DLBCL, we analysed 138 cases, using immunohistochemical methods. Methods and results: CD10 expression was limited to the cytoplasm, whereas Bcl10 expression was detected in the cytoplasm and/or nuclei. CD10 expression was detected in 39 of 138 cases (28.2%), cytoplasmic Bcl10 in 68 cases (49.2%), and nuclear Bcl10 in 34 cases (24.6%). Nuclear Bcl10 was detected in 14 of 28 cases (50%) of extranodal DLBCL, but only 20 of 110 cases (18.2%) of nodal DLBCL. Cytoplasmic Bcl10 was detected in 19 of 28 cases (67.8%) of extranodal DLBCL and 49 of 110 cases (44.5%) of nodal DLBCL. CD10 expression closely correlated with improved survival (68% overall survival (OS) vs. 48% OS), but not with site of disease. A high International Prognostic Index (IPI) was considered to be a poor prognostic factor associated with a shorter OS. CD10 expression was detected in 27 of 84 cases (32.1%) with low-risk IPIs, and in 12 of 54 cases (22.2%) with high-risk IPIs. In the low-risk group, cases expressing CD10 carried a better prognosis than CD10- cases (93% OS vs. 71% OS), whereas this was not the case in the high-risk group (25% vs. 20%). Conclusions: Bcl10 expression was associated with extranodal DLBCL, but not with prognosis. CD10 expression was closely associated with improved survival, but not with risk as predicted by IPI. Overall, our results suggest that CD10 expression may be useful, in combination with clinical parameters, for determining the prognosis of DLBCL.

Original languageEnglish
Pages (from-to)156-162
Number of pages7
JournalHistopathology
Volume39
Issue number2
DOIs
StatePublished - Dec 1 2001
Externally publishedYes

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Lymphoma, Large B-Cell, Diffuse
Cytoplasm
Marginal Zone B-Cell Lymphoma
Non-Hodgkin's Lymphoma
Genes
Cell Differentiation
B-Lymphocytes
Apoptosis

Keywords

  • B-cell
  • Bcl10
  • CD10
  • Lymphoma
  • Prognosis

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Cell Biology

Cite this

Ohshima, K., Kawasaki, C., Muta, H., Muta, K., Deyev, V., Haraoka, S., ... Kikuchi, M. (2001). CD10 and Bcl10 expression in diffuse large B-cell lymphoma: CD10 is a marker of improved prognosis. Histopathology, 39(2), 156-162. https://doi.org/10.1046/j.1365-2559.2001.01196.x

CD10 and Bcl10 expression in diffuse large B-cell lymphoma : CD10 is a marker of improved prognosis. / Ohshima, K.; Kawasaki, C.; Muta, H.; Muta, K.; Deyev, V.; Haraoka, S.; Suzumiya, J.; Podack, E. R.; Kikuchi, M.

In: Histopathology, Vol. 39, No. 2, 01.12.2001, p. 156-162.

Research output: Contribution to journalArticle

Ohshima, K, Kawasaki, C, Muta, H, Muta, K, Deyev, V, Haraoka, S, Suzumiya, J, Podack, ER & Kikuchi, M 2001, 'CD10 and Bcl10 expression in diffuse large B-cell lymphoma: CD10 is a marker of improved prognosis', Histopathology, vol. 39, no. 2, pp. 156-162. https://doi.org/10.1046/j.1365-2559.2001.01196.x
Ohshima, K. ; Kawasaki, C. ; Muta, H. ; Muta, K. ; Deyev, V. ; Haraoka, S. ; Suzumiya, J. ; Podack, E. R. ; Kikuchi, M. / CD10 and Bcl10 expression in diffuse large B-cell lymphoma : CD10 is a marker of improved prognosis. In: Histopathology. 2001 ; Vol. 39, No. 2. pp. 156-162.
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abstract = "Aims: Diffuse large B-cell lymphoma (DLBCL), the most common subtype of non-Hodgkin's lymphoma, is clinically and pathologically heterogeneous. The Bcl10 gene was recently isolated from the breakpoint region of t(1;14)(p22;q32) in mucosa-associated lymphoid tissue (MALT) lymphomas, and is considered to be an apoptosis-associated gene. CD10 is considered to be a marker of follicular centre B-cell differentiation. To assess the clinical significance and roles of CD10 and Bcl10 in DLBCL, we analysed 138 cases, using immunohistochemical methods. Methods and results: CD10 expression was limited to the cytoplasm, whereas Bcl10 expression was detected in the cytoplasm and/or nuclei. CD10 expression was detected in 39 of 138 cases (28.2{\%}), cytoplasmic Bcl10 in 68 cases (49.2{\%}), and nuclear Bcl10 in 34 cases (24.6{\%}). Nuclear Bcl10 was detected in 14 of 28 cases (50{\%}) of extranodal DLBCL, but only 20 of 110 cases (18.2{\%}) of nodal DLBCL. Cytoplasmic Bcl10 was detected in 19 of 28 cases (67.8{\%}) of extranodal DLBCL and 49 of 110 cases (44.5{\%}) of nodal DLBCL. CD10 expression closely correlated with improved survival (68{\%} overall survival (OS) vs. 48{\%} OS), but not with site of disease. A high International Prognostic Index (IPI) was considered to be a poor prognostic factor associated with a shorter OS. CD10 expression was detected in 27 of 84 cases (32.1{\%}) with low-risk IPIs, and in 12 of 54 cases (22.2{\%}) with high-risk IPIs. In the low-risk group, cases expressing CD10 carried a better prognosis than CD10- cases (93{\%} OS vs. 71{\%} OS), whereas this was not the case in the high-risk group (25{\%} vs. 20{\%}). Conclusions: Bcl10 expression was associated with extranodal DLBCL, but not with prognosis. CD10 expression was closely associated with improved survival, but not with risk as predicted by IPI. Overall, our results suggest that CD10 expression may be useful, in combination with clinical parameters, for determining the prognosis of DLBCL.",
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T1 - CD10 and Bcl10 expression in diffuse large B-cell lymphoma

T2 - CD10 is a marker of improved prognosis

AU - Ohshima, K.

AU - Kawasaki, C.

AU - Muta, H.

AU - Muta, K.

AU - Deyev, V.

AU - Haraoka, S.

AU - Suzumiya, J.

AU - Podack, E. R.

AU - Kikuchi, M.

PY - 2001/12/1

Y1 - 2001/12/1

N2 - Aims: Diffuse large B-cell lymphoma (DLBCL), the most common subtype of non-Hodgkin's lymphoma, is clinically and pathologically heterogeneous. The Bcl10 gene was recently isolated from the breakpoint region of t(1;14)(p22;q32) in mucosa-associated lymphoid tissue (MALT) lymphomas, and is considered to be an apoptosis-associated gene. CD10 is considered to be a marker of follicular centre B-cell differentiation. To assess the clinical significance and roles of CD10 and Bcl10 in DLBCL, we analysed 138 cases, using immunohistochemical methods. Methods and results: CD10 expression was limited to the cytoplasm, whereas Bcl10 expression was detected in the cytoplasm and/or nuclei. CD10 expression was detected in 39 of 138 cases (28.2%), cytoplasmic Bcl10 in 68 cases (49.2%), and nuclear Bcl10 in 34 cases (24.6%). Nuclear Bcl10 was detected in 14 of 28 cases (50%) of extranodal DLBCL, but only 20 of 110 cases (18.2%) of nodal DLBCL. Cytoplasmic Bcl10 was detected in 19 of 28 cases (67.8%) of extranodal DLBCL and 49 of 110 cases (44.5%) of nodal DLBCL. CD10 expression closely correlated with improved survival (68% overall survival (OS) vs. 48% OS), but not with site of disease. A high International Prognostic Index (IPI) was considered to be a poor prognostic factor associated with a shorter OS. CD10 expression was detected in 27 of 84 cases (32.1%) with low-risk IPIs, and in 12 of 54 cases (22.2%) with high-risk IPIs. In the low-risk group, cases expressing CD10 carried a better prognosis than CD10- cases (93% OS vs. 71% OS), whereas this was not the case in the high-risk group (25% vs. 20%). Conclusions: Bcl10 expression was associated with extranodal DLBCL, but not with prognosis. CD10 expression was closely associated with improved survival, but not with risk as predicted by IPI. Overall, our results suggest that CD10 expression may be useful, in combination with clinical parameters, for determining the prognosis of DLBCL.

AB - Aims: Diffuse large B-cell lymphoma (DLBCL), the most common subtype of non-Hodgkin's lymphoma, is clinically and pathologically heterogeneous. The Bcl10 gene was recently isolated from the breakpoint region of t(1;14)(p22;q32) in mucosa-associated lymphoid tissue (MALT) lymphomas, and is considered to be an apoptosis-associated gene. CD10 is considered to be a marker of follicular centre B-cell differentiation. To assess the clinical significance and roles of CD10 and Bcl10 in DLBCL, we analysed 138 cases, using immunohistochemical methods. Methods and results: CD10 expression was limited to the cytoplasm, whereas Bcl10 expression was detected in the cytoplasm and/or nuclei. CD10 expression was detected in 39 of 138 cases (28.2%), cytoplasmic Bcl10 in 68 cases (49.2%), and nuclear Bcl10 in 34 cases (24.6%). Nuclear Bcl10 was detected in 14 of 28 cases (50%) of extranodal DLBCL, but only 20 of 110 cases (18.2%) of nodal DLBCL. Cytoplasmic Bcl10 was detected in 19 of 28 cases (67.8%) of extranodal DLBCL and 49 of 110 cases (44.5%) of nodal DLBCL. CD10 expression closely correlated with improved survival (68% overall survival (OS) vs. 48% OS), but not with site of disease. A high International Prognostic Index (IPI) was considered to be a poor prognostic factor associated with a shorter OS. CD10 expression was detected in 27 of 84 cases (32.1%) with low-risk IPIs, and in 12 of 54 cases (22.2%) with high-risk IPIs. In the low-risk group, cases expressing CD10 carried a better prognosis than CD10- cases (93% OS vs. 71% OS), whereas this was not the case in the high-risk group (25% vs. 20%). Conclusions: Bcl10 expression was associated with extranodal DLBCL, but not with prognosis. CD10 expression was closely associated with improved survival, but not with risk as predicted by IPI. Overall, our results suggest that CD10 expression may be useful, in combination with clinical parameters, for determining the prognosis of DLBCL.

KW - B-cell

KW - Bcl10

KW - CD10

KW - Lymphoma

KW - Prognosis

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