Caveolae

A regulatory platform for nutritional modulation of inflammatory diseases

Joseph Layne, Zuzana Majkova, Eric J. Smart, Michal J Toborek, Bernhard Hennig

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Dietary intervention strategies have proven to be an effective means of decreasing several risk factors associated with the development of atherosclerosis. Endothelial cell dysfunction influences vascular inflammation and is involved in promoting the earliest stages of lesion formation. Caveolae are lipid raft microdomains abundant within the plasma membrane of endothelial cells and are responsible for modulating receptor-mediated signal transduction, thus influencing endothelial activation. Caveolae have been implicated in the regulation of enzymes associated with several key signaling pathways capable of determining intracellular redox status. Diet and plasma-derived nutrients may modulate an inflammatory outcome by interacting with and altering caveolae-associated cellular signaling. For example, omega-3 fatty acids and several polyphenolics have been shown to improve endothelial cell function by decreasing the formation of ROS and increasing NO bioavailability, events associated with altered caveolae composition. Thus, nutritional modulation of caveolae-mediated signaling events may provide an opportunity to ameliorate inflammatory signaling pathways capable of promoting the formation of vascular diseases, including atherosclerosis.

Original languageEnglish
Pages (from-to)807-811
Number of pages5
JournalJournal of Nutritional Biochemistry
Volume22
Issue number9
DOIs
StatePublished - Sep 1 2011
Externally publishedYes

Fingerprint

Caveolae
Endothelial cells
Modulation
Endothelial Cells
Cell signaling
Signal transduction
Omega-3 Fatty Acids
Cell membranes
Nutrition
Atherosclerosis
Nutrients
Chemical activation
Lipids
Plasmas
Vascular Diseases
Biological Availability
Oxidation-Reduction
Blood Vessels
Enzymes
Signal Transduction

Keywords

  • Caveolae
  • Inflammatory diseases
  • Nutritional modulation

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Molecular Biology
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Caveolae : A regulatory platform for nutritional modulation of inflammatory diseases. / Layne, Joseph; Majkova, Zuzana; Smart, Eric J.; Toborek, Michal J; Hennig, Bernhard.

In: Journal of Nutritional Biochemistry, Vol. 22, No. 9, 01.09.2011, p. 807-811.

Research output: Contribution to journalArticle

Layne, Joseph ; Majkova, Zuzana ; Smart, Eric J. ; Toborek, Michal J ; Hennig, Bernhard. / Caveolae : A regulatory platform for nutritional modulation of inflammatory diseases. In: Journal of Nutritional Biochemistry. 2011 ; Vol. 22, No. 9. pp. 807-811.
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