Causes of nonischemic sudden cardiac death in the current era

Eeva Hookana, M. Juhani Junttila, Veli Pekka Puurunen, Jani T. Tikkanen, Kari S. Kaikkonen, Marja Leena Kortelainen, Robert J Myerburg, Heikki V. Huikuri

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Abstract

Background: Previous data have shown that various nonischemic cardiac diseases account for about 20% of sudden cardiac deaths (SCDs) and that dilated and hypertrophic cardiomyopathy (CM) are major causes of nonischemic SCD. Objective: The purpose of this study was to define the prevalence and causes of SCD due to nonischemic CM in the current era given the substantial change in the diagnosis and treatment of cardiac diseases and in lifestyle patterns. Methods: A total of 2661 consecutive victims of SCD from among a population of approximately 470,000 inhabitants in the Province of Oulu, Northern Finland, were included in the study. The causes of deaths were determined from the uniformly required autopsies of SCD victims in Finland, plus available medical records and standardized questionnaires. Results: Nonischemic cause of SCD was found in 579 victims (21.8% of all the SCDs). Mean age (± SD) was 55 (±12) years; 78% were males. After subgrouping the nonischemic SCDs into various categories, SCDs associated most closely with obesity (23.7%), followed by alcoholic CM (19.0%), hypertensive CM (15.5%), and fibrotic CM (13.6%). Fibrotic CM was the most common association with SCD in subjects younger than 40 years (28.3%), whereas alcoholic CM was the most common cause of death in subjects between 40 and 59 years of age (25.8%). Conclusion: CM related to obesity, fibrotic CM, and alcoholic CM are commonly associated with nonischemic SCD in the current era. The association of SCD with fibrotic CM is notably frequent among victims younger than 40 years.

Original languageEnglish
Pages (from-to)1570-1575
Number of pages6
JournalHeart Rhythm
Volume8
Issue number10
DOIs
StatePublished - Oct 1 2011

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Sudden Cardiac Death
Cardiomyopathies
Alcoholic Cardiomyopathy
Finland
Cause of Death
Heart Diseases
Obesity
Hypertrophic Cardiomyopathy
Dilated Cardiomyopathy
Medical Records
Life Style
Autopsy

Keywords

  • Alcoholic cardiomyopathy
  • Cardiomyopathy
  • Epidemiology
  • Fibrosis
  • Medicolegal autopsy
  • Nonischemic sudden cardiac death

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Hookana, E., Junttila, M. J., Puurunen, V. P., Tikkanen, J. T., Kaikkonen, K. S., Kortelainen, M. L., ... Huikuri, H. V. (2011). Causes of nonischemic sudden cardiac death in the current era. Heart Rhythm, 8(10), 1570-1575. https://doi.org/10.1016/j.hrthm.2011.06.031

Causes of nonischemic sudden cardiac death in the current era. / Hookana, Eeva; Junttila, M. Juhani; Puurunen, Veli Pekka; Tikkanen, Jani T.; Kaikkonen, Kari S.; Kortelainen, Marja Leena; Myerburg, Robert J; Huikuri, Heikki V.

In: Heart Rhythm, Vol. 8, No. 10, 01.10.2011, p. 1570-1575.

Research output: Contribution to journalArticle

Hookana, E, Junttila, MJ, Puurunen, VP, Tikkanen, JT, Kaikkonen, KS, Kortelainen, ML, Myerburg, RJ & Huikuri, HV 2011, 'Causes of nonischemic sudden cardiac death in the current era', Heart Rhythm, vol. 8, no. 10, pp. 1570-1575. https://doi.org/10.1016/j.hrthm.2011.06.031
Hookana E, Junttila MJ, Puurunen VP, Tikkanen JT, Kaikkonen KS, Kortelainen ML et al. Causes of nonischemic sudden cardiac death in the current era. Heart Rhythm. 2011 Oct 1;8(10):1570-1575. https://doi.org/10.1016/j.hrthm.2011.06.031
Hookana, Eeva ; Junttila, M. Juhani ; Puurunen, Veli Pekka ; Tikkanen, Jani T. ; Kaikkonen, Kari S. ; Kortelainen, Marja Leena ; Myerburg, Robert J ; Huikuri, Heikki V. / Causes of nonischemic sudden cardiac death in the current era. In: Heart Rhythm. 2011 ; Vol. 8, No. 10. pp. 1570-1575.
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title = "Causes of nonischemic sudden cardiac death in the current era",
abstract = "Background: Previous data have shown that various nonischemic cardiac diseases account for about 20{\%} of sudden cardiac deaths (SCDs) and that dilated and hypertrophic cardiomyopathy (CM) are major causes of nonischemic SCD. Objective: The purpose of this study was to define the prevalence and causes of SCD due to nonischemic CM in the current era given the substantial change in the diagnosis and treatment of cardiac diseases and in lifestyle patterns. Methods: A total of 2661 consecutive victims of SCD from among a population of approximately 470,000 inhabitants in the Province of Oulu, Northern Finland, were included in the study. The causes of deaths were determined from the uniformly required autopsies of SCD victims in Finland, plus available medical records and standardized questionnaires. Results: Nonischemic cause of SCD was found in 579 victims (21.8{\%} of all the SCDs). Mean age (± SD) was 55 (±12) years; 78{\%} were males. After subgrouping the nonischemic SCDs into various categories, SCDs associated most closely with obesity (23.7{\%}), followed by alcoholic CM (19.0{\%}), hypertensive CM (15.5{\%}), and fibrotic CM (13.6{\%}). Fibrotic CM was the most common association with SCD in subjects younger than 40 years (28.3{\%}), whereas alcoholic CM was the most common cause of death in subjects between 40 and 59 years of age (25.8{\%}). Conclusion: CM related to obesity, fibrotic CM, and alcoholic CM are commonly associated with nonischemic SCD in the current era. The association of SCD with fibrotic CM is notably frequent among victims younger than 40 years.",
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T1 - Causes of nonischemic sudden cardiac death in the current era

AU - Hookana, Eeva

AU - Junttila, M. Juhani

AU - Puurunen, Veli Pekka

AU - Tikkanen, Jani T.

AU - Kaikkonen, Kari S.

AU - Kortelainen, Marja Leena

AU - Myerburg, Robert J

AU - Huikuri, Heikki V.

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N2 - Background: Previous data have shown that various nonischemic cardiac diseases account for about 20% of sudden cardiac deaths (SCDs) and that dilated and hypertrophic cardiomyopathy (CM) are major causes of nonischemic SCD. Objective: The purpose of this study was to define the prevalence and causes of SCD due to nonischemic CM in the current era given the substantial change in the diagnosis and treatment of cardiac diseases and in lifestyle patterns. Methods: A total of 2661 consecutive victims of SCD from among a population of approximately 470,000 inhabitants in the Province of Oulu, Northern Finland, were included in the study. The causes of deaths were determined from the uniformly required autopsies of SCD victims in Finland, plus available medical records and standardized questionnaires. Results: Nonischemic cause of SCD was found in 579 victims (21.8% of all the SCDs). Mean age (± SD) was 55 (±12) years; 78% were males. After subgrouping the nonischemic SCDs into various categories, SCDs associated most closely with obesity (23.7%), followed by alcoholic CM (19.0%), hypertensive CM (15.5%), and fibrotic CM (13.6%). Fibrotic CM was the most common association with SCD in subjects younger than 40 years (28.3%), whereas alcoholic CM was the most common cause of death in subjects between 40 and 59 years of age (25.8%). Conclusion: CM related to obesity, fibrotic CM, and alcoholic CM are commonly associated with nonischemic SCD in the current era. The association of SCD with fibrotic CM is notably frequent among victims younger than 40 years.

AB - Background: Previous data have shown that various nonischemic cardiac diseases account for about 20% of sudden cardiac deaths (SCDs) and that dilated and hypertrophic cardiomyopathy (CM) are major causes of nonischemic SCD. Objective: The purpose of this study was to define the prevalence and causes of SCD due to nonischemic CM in the current era given the substantial change in the diagnosis and treatment of cardiac diseases and in lifestyle patterns. Methods: A total of 2661 consecutive victims of SCD from among a population of approximately 470,000 inhabitants in the Province of Oulu, Northern Finland, were included in the study. The causes of deaths were determined from the uniformly required autopsies of SCD victims in Finland, plus available medical records and standardized questionnaires. Results: Nonischemic cause of SCD was found in 579 victims (21.8% of all the SCDs). Mean age (± SD) was 55 (±12) years; 78% were males. After subgrouping the nonischemic SCDs into various categories, SCDs associated most closely with obesity (23.7%), followed by alcoholic CM (19.0%), hypertensive CM (15.5%), and fibrotic CM (13.6%). Fibrotic CM was the most common association with SCD in subjects younger than 40 years (28.3%), whereas alcoholic CM was the most common cause of death in subjects between 40 and 59 years of age (25.8%). Conclusion: CM related to obesity, fibrotic CM, and alcoholic CM are commonly associated with nonischemic SCD in the current era. The association of SCD with fibrotic CM is notably frequent among victims younger than 40 years.

KW - Alcoholic cardiomyopathy

KW - Cardiomyopathy

KW - Epidemiology

KW - Fibrosis

KW - Medicolegal autopsy

KW - Nonischemic sudden cardiac death

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