Cause, seasonality of death and co-morbidities in progressive supranuclear palsy (PSP)

Spiridon Papapetropoulos; Carlos Singer; Donald McCorquodale; Jocely Gonzalez; Deborah C. Mash

doi:10.1016/j.parkreldis.2005.06.003

Cause, seasonality of death and co-morbidities in progressive supranuclear palsy (PSP)

Spiridon Papapetropoulos, Carlos Singer, Donald McCorquodale, Jocely Gonzalez, Deborah C. Mash

Neurology

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

The aim of this study was to investigate the causes and seasonality of death and co-morbid conditions among progressive supranuclear palsy (PSP) patients. 22 consecutive clinicopathologically confirmed PSP patients were compared with 22 gender and age-matched Parkinson's disease (PD) patients and 26 non-neurological controls. All subjects consented during life to donate their brains to the University of Miami Brain Endowment Bank™. Respiratory-related deaths were significantly more frequent in PSP when compared to PD patients. Recurrent respiratory infections were also very frequent in PSP patients and were commonly associated with respiratory-related deaths. Deaths that occurred during winter and spring months accounted for about 70% of deaths among PSP patients. The most common co-morbid condition in PSP was hypertension, present in 50% of cases.

Original language	English (US)
Pages (from-to)	459-463
Number of pages	5
Journal	Parkinsonism and Related Disorders
Volume	11
Issue number	7
DOIs	https://doi.org/10.1016/j.parkreldis.2005.06.003
State	Published - Nov 1 2005

Keywords

Brain donors
Cause of death
Post-mortem
Progressive supranuclear palsy
Seasonality

ASJC Scopus subject areas

Aging
Clinical Neurology
Neurology

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abstract = "The aim of this study was to investigate the causes and seasonality of death and co-morbid conditions among progressive supranuclear palsy (PSP) patients. 22 consecutive clinicopathologically confirmed PSP patients were compared with 22 gender and age-matched Parkinson's disease (PD) patients and 26 non-neurological controls. All subjects consented during life to donate their brains to the University of Miami Brain Endowment Bank{\texttrademark}. Respiratory-related deaths were significantly more frequent in PSP when compared to PD patients. Recurrent respiratory infections were also very frequent in PSP patients and were commonly associated with respiratory-related deaths. Deaths that occurred during winter and spring months accounted for about 70% of deaths among PSP patients. The most common co-morbid condition in PSP was hypertension, present in 50% of cases.",

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