Cause, seasonality of death and co-morbidities in progressive supranuclear palsy (PSP)

Spiridon Papapetropoulos, Carlos Singer, Donald McCorquodale, Jocely Gonzalez, Deborah C. Mash

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


The aim of this study was to investigate the causes and seasonality of death and co-morbid conditions among progressive supranuclear palsy (PSP) patients. 22 consecutive clinicopathologically confirmed PSP patients were compared with 22 gender and age-matched Parkinson's disease (PD) patients and 26 non-neurological controls. All subjects consented during life to donate their brains to the University of Miami Brain Endowment Bank™. Respiratory-related deaths were significantly more frequent in PSP when compared to PD patients. Recurrent respiratory infections were also very frequent in PSP patients and were commonly associated with respiratory-related deaths. Deaths that occurred during winter and spring months accounted for about 70% of deaths among PSP patients. The most common co-morbid condition in PSP was hypertension, present in 50% of cases.

Original languageEnglish (US)
Pages (from-to)459-463
Number of pages5
JournalParkinsonism and Related Disorders
Issue number7
StatePublished - Nov 2005


  • Brain donors
  • Cause of death
  • Post-mortem
  • Progressive supranuclear palsy
  • Seasonality

ASJC Scopus subject areas

  • Aging
  • Clinical Neurology
  • Neurology


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