Caudate Hyperintensities in Elderly Depressed Patients With Neuroleptic-Induced Parkinsonism

Gary S. Figiel, K. Ranga R. Krishnan, P. Murali Doraiswamy, Charles B. Nemeroff

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Elderly patients are particularly sensitive to the neurologic side effects of psychotropic medications. This increased sensitivity may be related to brain structural changes associated with aging. In this pilot study, the authors report on the occurrence of caudate hyperintensities, using brain magnetic resonance imaging, in seven elderly depressed subjects who developed neuroleptic-induced parkinsonism. Caudate hyperintensities were not observed in any of the seven healthy elderly controls examined. These results suggest that caudate hyperintensities may render some elderly depressed patients susceptible to neuroleptic-induced parkinsonism.

Original languageEnglish (US)
Pages (from-to)86-89
Number of pages4
JournalJournal of Geriatric Psychiatry and Neurology
Issue number2
StatePublished - Apr 1991
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health


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