Caudate Hyperintensities in Elderly Depressed Patients With Neuroleptic-Induced Parkinsonism

Gary S. Figiel; K. Ranga R. Krishnan; P. Murali Doraiswamy; Charles B. Nemeroff

doi:10.1177/089198879100400206

Caudate Hyperintensities in Elderly Depressed Patients With Neuroleptic-Induced Parkinsonism

Gary S. Figiel, K. Ranga R. Krishnan, P. Murali Doraiswamy, Charles B. Nemeroff

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Elderly patients are particularly sensitive to the neurologic side effects of psychotropic medications. This increased sensitivity may be related to brain structural changes associated with aging. In this pilot study, the authors report on the occurrence of caudate hyperintensities, using brain magnetic resonance imaging, in seven elderly depressed subjects who developed neuroleptic-induced parkinsonism. Caudate hyperintensities were not observed in any of the seven healthy elderly controls examined. These results suggest that caudate hyperintensities may render some elderly depressed patients susceptible to neuroleptic-induced parkinsonism.

Original language	English (US)
Pages (from-to)	86-89
Number of pages	4
Journal	Journal of Geriatric Psychiatry and Neurology
Volume	4
Issue number	2
DOIs	https://doi.org/10.1177/089198879100400206
State	Published - Apr 1991
Externally published	Yes

ASJC Scopus subject areas

Clinical Neurology
Geriatrics and Gerontology
Psychiatry and Mental health

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