TY - JOUR
T1 - Ca2+-induced Ca2+ release in insulin-secreting cells
AU - Islam, Md Shahidul
AU - Rorsman, Patrik
AU - Berggren, Per Olof
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1992/1/27
Y1 - 1992/1/27
N2 - The sulphydryl reagent thimerosal (50 μM) released Ca2+ from a non-mitochondrial intracellular Ca2+ pool in a dose-dependent manner in permeabilized insulin-secreting RINm5F cells. This release was reversed after addition of the reducing agent dithiothreitol, Ca2+ was released from an Ins(1,4,5)P3-insensitive pool, since release was observed even after depletion of the Ins(1,4,5)P3-sensitive pool by a supramaximal dose of Ins(2,4,5)P3 or thapsigargin. The Ins(1,4,5)P3-sensitive pool remained essentially unaltered by thimerosal. Thimerosal-induced Ca2+ release was potentiated by caffeine. These findings suggest the existence of Ca2+-induced Ca2+ release also in insulin-secreting cells.
AB - The sulphydryl reagent thimerosal (50 μM) released Ca2+ from a non-mitochondrial intracellular Ca2+ pool in a dose-dependent manner in permeabilized insulin-secreting RINm5F cells. This release was reversed after addition of the reducing agent dithiothreitol, Ca2+ was released from an Ins(1,4,5)P3-insensitive pool, since release was observed even after depletion of the Ins(1,4,5)P3-sensitive pool by a supramaximal dose of Ins(2,4,5)P3 or thapsigargin. The Ins(1,4,5)P3-sensitive pool remained essentially unaltered by thimerosal. Thimerosal-induced Ca2+ release was potentiated by caffeine. These findings suggest the existence of Ca2+-induced Ca2+ release also in insulin-secreting cells.
KW - Ca-induced Ca release
KW - Insulin-secreting cell
KW - Intracellular Ca transport
KW - Permeabilized cell
KW - Sulphydryl reagent
KW - Thimerosal
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U2 - 10.1016/0014-5793(92)80306-2
DO - 10.1016/0014-5793(92)80306-2
M3 - Article
C2 - 1537406
AN - SCOPUS:0026565989
VL - 296
SP - 287
EP - 291
JO - FEBS Letters
JF - FEBS Letters
SN - 0014-5793
IS - 3
ER -