Caspase inhibitors prevent cisplatin-induced apoptosis of auditory sensory cells

Wei Liu, Hinrich Staecker, Howard Stupak, Brigitte Malgrange, Philippe Lefebvre, Thomas R. Van De Water

Research output: Contribution to journalArticle

130 Scopus citations

Abstract

In vitro studies tested the efficacy of three caspase inhibitors, Ac- VAD-cmk (caspase-1 inhibitor), z-DEVD-fmk (caspase -3 inhibitor) and B-D-fmk (BOCDFK, a general inhibitor), for protecting auditory sensory cells from cisplatin-damage induced loss. Treatment of 3-day-old rat organ of Corti explants with these caspase inhibitors protected > 80% of the auditory hair cells from cisplatin-damage initiated apoptosis. Dissociated cell cultures of 3-day-old rat spinal ganglia treated with any of these three caspase inhibitors in addition to exogenous neurotrophin have highly significant increases in neuronal survival following cisplatin exposure. These results indicate that loss of auditory sensory cells as a result of cisplatin- induced damage involves apoptosis and that blocking of this cell death pathway at the caspase level effectively rescues both hair cells and neurons.

Original languageEnglish (US)
Pages (from-to)2609-2614
Number of pages6
JournalNeuroreport
Volume9
Issue number11
DOIs
StatePublished - Aug 3 1998

Keywords

  • Apoptosis
  • Auditory sensory cells
  • Caspase inhibitors
  • Caspases
  • Cisplatin damage
  • Protection

ASJC Scopus subject areas

  • Neuroscience(all)

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    Liu, W., Staecker, H., Stupak, H., Malgrange, B., Lefebvre, P., & Van De Water, T. R. (1998). Caspase inhibitors prevent cisplatin-induced apoptosis of auditory sensory cells. Neuroreport, 9(11), 2609-2614. https://doi.org/10.1097/00001756-199808030-00034