Casein kinase 1-dependent wee1 protein degradation

Lara Penas, Vimal Ramachandran, Scott Simanski, Choogon Lee, Franck Madoux, Ronald J. Rahaim, Ruchi Chauhan, Omar Barnaby, Stephan Schurer, Peter Hodder, Judith Steen, William R. Roush, Nagi G. Ayad

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Background: Wee1 is an essential gene in mammals that encodes the cell cycle and cancer associated protein Wee1 kinase. Results: Inhibition of CK1- kinase increases the levels of Wee1 protein kinase. Conclusion: Casein kinase 1- is required for Wee1 degradation in HeLa cells and mouse embryonic fibroblasts. Significance: This is a previously unappreciated role for CK1- in controlling Wee1 degradation and cell cycle progression.

Original languageEnglish (US)
Pages (from-to)18893-18903
Number of pages11
JournalJournal of Biological Chemistry
Volume289
Issue number27
DOIs
StatePublished - Jul 4 2014

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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