Casein kinase 1-dependent wee1 protein degradation

Lara Penas, Vimal Ramachandran, Scott Simanski, Choogon Lee, Franck Madoux, Ronald J. Rahaim, Ruchi Chauhan, Omar Barnaby, Stephan C Schuerer, Peter Hodder, Judith Steen, William R. Roush, Nagi Ayad

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background: Wee1 is an essential gene in mammals that encodes the cell cycle and cancer associated protein Wee1 kinase. Results: Inhibition of CK1- kinase increases the levels of Wee1 protein kinase. Conclusion: Casein kinase 1- is required for Wee1 degradation in HeLa cells and mouse embryonic fibroblasts. Significance: This is a previously unappreciated role for CK1- in controlling Wee1 degradation and cell cycle progression.

Original languageEnglish
Pages (from-to)18893-18903
Number of pages11
JournalJournal of Biological Chemistry
Volume289
Issue number27
DOIs
StatePublished - Jul 4 2014

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Casein Kinase I
Protein Kinases
Proteolysis
Cell Cycle
Phosphotransferases
Cells
Degradation
Mammals
Essential Genes
Fibroblasts
HeLa Cells
Proteins
Genes
Neoplasms

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

Penas, L., Ramachandran, V., Simanski, S., Lee, C., Madoux, F., Rahaim, R. J., ... Ayad, N. (2014). Casein kinase 1-dependent wee1 protein degradation. Journal of Biological Chemistry, 289(27), 18893-18903. https://doi.org/10.1074/jbc.M114.547661

Casein kinase 1-dependent wee1 protein degradation. / Penas, Lara; Ramachandran, Vimal; Simanski, Scott; Lee, Choogon; Madoux, Franck; Rahaim, Ronald J.; Chauhan, Ruchi; Barnaby, Omar; Schuerer, Stephan C; Hodder, Peter; Steen, Judith; Roush, William R.; Ayad, Nagi.

In: Journal of Biological Chemistry, Vol. 289, No. 27, 04.07.2014, p. 18893-18903.

Research output: Contribution to journalArticle

Penas, L, Ramachandran, V, Simanski, S, Lee, C, Madoux, F, Rahaim, RJ, Chauhan, R, Barnaby, O, Schuerer, SC, Hodder, P, Steen, J, Roush, WR & Ayad, N 2014, 'Casein kinase 1-dependent wee1 protein degradation', Journal of Biological Chemistry, vol. 289, no. 27, pp. 18893-18903. https://doi.org/10.1074/jbc.M114.547661
Penas L, Ramachandran V, Simanski S, Lee C, Madoux F, Rahaim RJ et al. Casein kinase 1-dependent wee1 protein degradation. Journal of Biological Chemistry. 2014 Jul 4;289(27):18893-18903. https://doi.org/10.1074/jbc.M114.547661
Penas, Lara ; Ramachandran, Vimal ; Simanski, Scott ; Lee, Choogon ; Madoux, Franck ; Rahaim, Ronald J. ; Chauhan, Ruchi ; Barnaby, Omar ; Schuerer, Stephan C ; Hodder, Peter ; Steen, Judith ; Roush, William R. ; Ayad, Nagi. / Casein kinase 1-dependent wee1 protein degradation. In: Journal of Biological Chemistry. 2014 ; Vol. 289, No. 27. pp. 18893-18903.
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