Abstract
This is a case study of an 88-year-old man who presented with agenesis of the corpus callosum and colpocephaly. Symptomatically, he reported a sudden onset of mild, intermittent left hand apraxia, but denied any previous manifestations consistent with this type of brain malformation. The patient underwent neuroimaging, evaluation by neurology, and comprehensive neuropsychological testing to determine the nature of any other associated impairments. Test results indicated that he was, with a few exceptions, neuropsychologically normal. He performed well on tests that are highly sensitive to acquired brain dysfunction. His most notable deficit was failed performance in the simultaneous and coordinated use of both hands in using tactile and proprioceptive feedback on the Tactual Performance Test. This case is discussed in terms of plasticity of the developing brain, including compensatory mechanisms, highlighting the variability in clinical outcome in the context of congenital brain malformation. This case study illustrates the strong influence of cerebral plasticity as well as a possible circumscribed manifestation of interhemispheric disconnection.
| Original language | English |
|---|---|
| Pages (from-to) | 606-614 |
| Number of pages | 9 |
| Journal | Neurocase |
| Volume | 20 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jan 1 2014 |
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Keywords
- Aging
- Apraxia
- Corpus callosum agenesis
- Corpus callosum dysgenesis
- Neuropsychology
ASJC Scopus subject areas
- Clinical Neurology
- Arts and Humanities (miscellaneous)
Cite this
Case study : A patient with agenesis of the corpus callosum with minimal associated neuropsychological impairment. / Brescian, Natalie E.; Curiel Cid, Rosie; Gass, Carlton S.
In: Neurocase, Vol. 20, No. 6, 01.01.2014, p. 606-614.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Case study
T2 - A patient with agenesis of the corpus callosum with minimal associated neuropsychological impairment
AU - Brescian, Natalie E.
AU - Curiel Cid, Rosie
AU - Gass, Carlton S.
PY - 2014/1/1
Y1 - 2014/1/1
N2 - This is a case study of an 88-year-old man who presented with agenesis of the corpus callosum and colpocephaly. Symptomatically, he reported a sudden onset of mild, intermittent left hand apraxia, but denied any previous manifestations consistent with this type of brain malformation. The patient underwent neuroimaging, evaluation by neurology, and comprehensive neuropsychological testing to determine the nature of any other associated impairments. Test results indicated that he was, with a few exceptions, neuropsychologically normal. He performed well on tests that are highly sensitive to acquired brain dysfunction. His most notable deficit was failed performance in the simultaneous and coordinated use of both hands in using tactile and proprioceptive feedback on the Tactual Performance Test. This case is discussed in terms of plasticity of the developing brain, including compensatory mechanisms, highlighting the variability in clinical outcome in the context of congenital brain malformation. This case study illustrates the strong influence of cerebral plasticity as well as a possible circumscribed manifestation of interhemispheric disconnection.
AB - This is a case study of an 88-year-old man who presented with agenesis of the corpus callosum and colpocephaly. Symptomatically, he reported a sudden onset of mild, intermittent left hand apraxia, but denied any previous manifestations consistent with this type of brain malformation. The patient underwent neuroimaging, evaluation by neurology, and comprehensive neuropsychological testing to determine the nature of any other associated impairments. Test results indicated that he was, with a few exceptions, neuropsychologically normal. He performed well on tests that are highly sensitive to acquired brain dysfunction. His most notable deficit was failed performance in the simultaneous and coordinated use of both hands in using tactile and proprioceptive feedback on the Tactual Performance Test. This case is discussed in terms of plasticity of the developing brain, including compensatory mechanisms, highlighting the variability in clinical outcome in the context of congenital brain malformation. This case study illustrates the strong influence of cerebral plasticity as well as a possible circumscribed manifestation of interhemispheric disconnection.
KW - Aging
KW - Apraxia
KW - Corpus callosum agenesis
KW - Corpus callosum dysgenesis
KW - Neuropsychology
UR - http://www.scopus.com/inward/record.url?scp=84905113665&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84905113665&partnerID=8YFLogxK
U2 - 10.1080/13554794.2013.826690
DO - 10.1080/13554794.2013.826690
M3 - Article
C2 - 23962137
AN - SCOPUS:84905113665
VL - 20
SP - 606
EP - 614
JO - Neurocase
JF - Neurocase
SN - 1355-4794
IS - 6
ER -