Case study: A patient with agenesis of the corpus callosum with minimal associated neuropsychological impairment

Natalie E. Brescian, Rosie E. Curiel, Carlton S. Gass

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

This is a case study of an 88-year-old man who presented with agenesis of the corpus callosum and colpocephaly. Symptomatically, he reported a sudden onset of mild, intermittent left hand apraxia, but denied any previous manifestations consistent with this type of brain malformation. The patient underwent neuroimaging, evaluation by neurology, and comprehensive neuropsychological testing to determine the nature of any other associated impairments. Test results indicated that he was, with a few exceptions, neuropsychologically normal. He performed well on tests that are highly sensitive to acquired brain dysfunction. His most notable deficit was failed performance in the simultaneous and coordinated use of both hands in using tactile and proprioceptive feedback on the Tactual Performance Test. This case is discussed in terms of plasticity of the developing brain, including compensatory mechanisms, highlighting the variability in clinical outcome in the context of congenital brain malformation. This case study illustrates the strong influence of cerebral plasticity as well as a possible circumscribed manifestation of interhemispheric disconnection.

Original languageEnglish (US)
Pages (from-to)606-614
Number of pages9
JournalNeurocase
Volume20
Issue number6
DOIs
StatePublished - Nov 2014

Keywords

  • Aging
  • Apraxia
  • Corpus callosum agenesis
  • Corpus callosum dysgenesis
  • Neuropsychology

ASJC Scopus subject areas

  • Clinical Neurology
  • Arts and Humanities (miscellaneous)

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