TY - JOUR
T1 - Case series of multisystem inflammatory syndrome in adults associated with SARS-CoV-2 infection ⇔ United Kingdom and United States, March–August 2020
AU - Morris, Sapna Bamrah
AU - Schwartz, Noah G.
AU - Patel, Pragna
AU - Abbo, Lilian
AU - Beauchamps, Laura
AU - Balan, Shuba
AU - Lee, Ellen H.
AU - Paneth-Pollak, Rachel
AU - Geevarughese, Anita
AU - Lash, Maura K.
AU - Dorsinville, Marie S.
AU - Ballen, Vennus
AU - Eiras, Daniel P.
AU - Newton-Cheh, Christopher
AU - Smith, Emer
AU - Robinson, Sara
AU - Stogsdill, Patricia
AU - Lim, Sarah
AU - Fox, Sharon E.
AU - Richardson, Gillian
AU - Hand, Julie
AU - Oliver, Nora T.
AU - Kofman, Aaron
AU - Bryant, Bobbi
AU - Ende, Zachary
AU - Datta, Deblina
AU - Belay, Ermias
AU - Godfred-Cato, Shana
N1 - Funding Information:
All authors have completed and submitted the International Committee of Medical Journal Editors form for disclosure of potential conflicts of interest. Lilian Abbo reports personal fees from Pfizer, Merck/MSD, Nabriva Therapeutics, Roche Diagnostics, Paratek, and Achaogen, outside the submitted work. Sharon E. Fox reports personal fees from Boehringer Ingelheim, outside the submitted work. Christopher Newton-Cheh reports grants from the National Institutes of Health, and personal fees from GE Healthcare, and Novartis, outside the submitted work. No other potential conflicts of interest were disclosed.
PY - 2020/10/9
Y1 - 2020/10/9
N2 - What is already known about this topic? Multisystem inflammatory syndrome in children (MIS-C) is a rare but severe complication of SARS-CoV-2 infection in children and adolescents. Since June 2020, several case reports and series have been published reporting a similar multisystem inflammatory syndrome in adults (MIS-A). What is added by this report? Cases reported to CDC and published case reports and series identify MIS-A in adults, who usually require intensive care and can have fatal outcomes. Antibody testing was required to identify SARS-CoV-2 infection in approximately one third of 27 cases. What are the implications for public health practice? Clinical suspicion and indicated SARS-CoV-2 testing, including antibody testing, might be needed to recognize and treat adults with MIS-A. Further research is needed to understand the pathogenesis and long-term effects of this condition. Ultimately, the recognition of MIS-A reinforces the need for prevention efforts to limit spread of SARS-CoV-2.
AB - What is already known about this topic? Multisystem inflammatory syndrome in children (MIS-C) is a rare but severe complication of SARS-CoV-2 infection in children and adolescents. Since June 2020, several case reports and series have been published reporting a similar multisystem inflammatory syndrome in adults (MIS-A). What is added by this report? Cases reported to CDC and published case reports and series identify MIS-A in adults, who usually require intensive care and can have fatal outcomes. Antibody testing was required to identify SARS-CoV-2 infection in approximately one third of 27 cases. What are the implications for public health practice? Clinical suspicion and indicated SARS-CoV-2 testing, including antibody testing, might be needed to recognize and treat adults with MIS-A. Further research is needed to understand the pathogenesis and long-term effects of this condition. Ultimately, the recognition of MIS-A reinforces the need for prevention efforts to limit spread of SARS-CoV-2.
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U2 - 10.15585/mmwr.mm6940e1
DO - 10.15585/mmwr.mm6940e1
M3 - Article
C2 - 33031361
AN - SCOPUS:85092683837
VL - 69
SP - 1450
EP - 1456
JO - Morbidity and Mortality Weekly Report
JF - Morbidity and Mortality Weekly Report
SN - 0149-2195
IS - 40
ER -