TY - JOUR
T1 - Case series of multisystem inflammatory syndrome in adults associated with SARS-CoV-2 infection ⇔ United Kingdom and United States, March–August 2020
AU - Morris, Sapna Bamrah
AU - Schwartz, Noah G.
AU - Patel, Pragna
AU - Abbo, Lilian
AU - Beauchamps, Laura
AU - Balan, Shuba
AU - Lee, Ellen H.
AU - Paneth-Pollak, Rachel
AU - Geevarughese, Anita
AU - Lash, Maura K.
AU - Dorsinville, Marie S.
AU - Ballen, Vennus
AU - Eiras, Daniel P.
AU - Newton-Cheh, Christopher
AU - Smith, Emer
AU - Robinson, Sara
AU - Stogsdill, Patricia
AU - Lim, Sarah
AU - Fox, Sharon E.
AU - Richardson, Gillian
AU - Hand, Julie
AU - Oliver, Nora T.
AU - Kofman, Aaron
AU - Bryant, Bobbi
AU - Ende, Zachary
AU - Datta, Deblina
AU - Belay, Ermias
AU - Godfred-Cato, Shana
N1 - Funding Information:
All authors have completed and submitted the International Committee of Medical Journal Editors form for disclosure of potential conflicts of interest. Lilian Abbo reports personal fees from Pfizer, Merck/MSD, Nabriva Therapeutics, Roche Diagnostics, Paratek, and Achaogen, outside the submitted work. Sharon E. Fox reports personal fees from Boehringer Ingelheim, outside the submitted work. Christopher Newton-Cheh reports grants from the National Institutes of Health, and personal fees from GE Healthcare, and Novartis, outside the submitted work. No other potential conflicts of interest were disclosed.
Publisher Copyright:
© 2020 Department of Health and Human Services. All rights reserved.
PY - 2020/10/9
Y1 - 2020/10/9
N2 - What is already known about this topic? Multisystem inflammatory syndrome in children (MIS-C) is a rare but severe complication of SARS-CoV-2 infection in children and adolescents. Since June 2020, several case reports and series have been published reporting a similar multisystem inflammatory syndrome in adults (MIS-A). What is added by this report? Cases reported to CDC and published case reports and series identify MIS-A in adults, who usually require intensive care and can have fatal outcomes. Antibody testing was required to identify SARS-CoV-2 infection in approximately one third of 27 cases. What are the implications for public health practice? Clinical suspicion and indicated SARS-CoV-2 testing, including antibody testing, might be needed to recognize and treat adults with MIS-A. Further research is needed to understand the pathogenesis and long-term effects of this condition. Ultimately, the recognition of MIS-A reinforces the need for prevention efforts to limit spread of SARS-CoV-2.
AB - What is already known about this topic? Multisystem inflammatory syndrome in children (MIS-C) is a rare but severe complication of SARS-CoV-2 infection in children and adolescents. Since June 2020, several case reports and series have been published reporting a similar multisystem inflammatory syndrome in adults (MIS-A). What is added by this report? Cases reported to CDC and published case reports and series identify MIS-A in adults, who usually require intensive care and can have fatal outcomes. Antibody testing was required to identify SARS-CoV-2 infection in approximately one third of 27 cases. What are the implications for public health practice? Clinical suspicion and indicated SARS-CoV-2 testing, including antibody testing, might be needed to recognize and treat adults with MIS-A. Further research is needed to understand the pathogenesis and long-term effects of this condition. Ultimately, the recognition of MIS-A reinforces the need for prevention efforts to limit spread of SARS-CoV-2.
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U2 - 10.15585/mmwr.mm6940e1
DO - 10.15585/mmwr.mm6940e1
M3 - Article
C2 - 33031361
AN - SCOPUS:85092683837
VL - 69
SP - 1450
EP - 1456
JO - Morbidity and Mortality Weekly Report
JF - Morbidity and Mortality Weekly Report
SN - 0149-2195
IS - 40
ER -