Case of Bullous Grover Disease

Yumeng M. Li, Clara Milikowski, Fabrizio Galimberti

Research output: Contribution to journalArticlepeer-review


ABSTRACT: Grover disease is an acquired acantholytic dermatosis affecting middle-aged men, with pruritus being the most commonly associated symptom. Grover disease tends to wax and wane and can last between several months to several years. Although Grover disease is usually papular, we report here a patient who presented with mainly vesicular and bullous lesions on his back originally concerning for folliculitis, contact dermatitis, or disseminated herpes simplex viral infection. Skin biopsy demonstrated acantholysis, suprabasal blisters, and a predominantly lymphocytic dermal infiltrate. Tzanck preparation for giant cells, immunohistochemistry for viral markers, and direct immunofluorescence staining were all negative. A diagnosis of bullous Grover disease was made based on clinicopathological correlation. Minocycline was recommended based on report of its efficacy. However, patient declined treatment and his rash self-resolved within a couple of months. This case brings awareness to this atypical variant of Grover disease and encourages physician to include Grover disease in their differential of vesiculobullous disorders.

Original languageEnglish (US)
Pages (from-to)141-143
Number of pages3
JournalThe American Journal of dermatopathology
Issue number2
StatePublished - Feb 1 2021

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Dermatology


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