Case 48-1980: Rapidly Progressive Neurologic Disorder Following Gastrointestinal Symptoms

Richard C. Cabot, Robert E. Scully, James J. Galdabini, Betty U. Mcneely, Walter G. Bradley, Bhagwan T. Shahani, Newton E. Hyslop

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8 Scopus citations


A CPC is presented in which a 47 year old man develops a rapidly progressive neurological illness following an acute gastrointestinal disorder. His illness was characterized by ptosis, ophthalmoplegia, dysphagia, palatal, facial and limb weakness (with preservation of deep tendon reflexes), diminished vital capacity, paralytic ileus, and hypotension. A clinical diagnosis of botulism was supported by electrophysiologic studies - postexercise facilitation, and abnormal jitter on single fiber EMG, and confirmed by finding Type B, C. botulinum and toxin in the patients stool specimen. The patient was treated with botulinal antitoxin and recovered completely over the ensuing 2 months. The differential diagnosis, and pathophysiology of botulism is discussed. (S.D. Cook, Newark, N.J.)

Original languageEnglish (US)
Pages (from-to)1347-1355
Number of pages9
JournalNew England Journal of Medicine
Issue number23
StatePublished - Dec 4 1980
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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