Cartilage metalloproteases in disuse atrophy

R. M. Grumbles, D. S. Howell, G. A. Howard, Bernard A Roos, L. A. Setton, C. Mow, A. Ratcliffe, F. J. Muller, R. D. Altman

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


A canine knee model of disuse atrophy produced by nonrigid fixation (sling) was characterized in respect to variables of proteoglycan size distribution, as well as biomechanical properties versus controls. Using this model, we found, in addition to the accepted dogma attributing changes to reduced protein synthesis by chondrocytes, that there is elevation of proteases and depression of tissue inhibitor of metalloproteases (TIMP) in atrophic knee cartilage. The findings are suggestive of cartilage remodelling reminiscent of bone remodelling in disuse atrophy reported by others. Whether the abnormal changes of protease-TIMP balance in knee cartilage can be retarded prophylactically by concurrent treatment with pentosan polysulfate and insulin like growth factor 1 remains uncertain.

Original languageEnglish (US)
Pages (from-to)146-148
Number of pages3
JournalJournal of Rheumatology
Issue numberSUPPL. 43
StatePublished - Jan 1 1995


  • Cartilage atrophy
  • Chondroprotection
  • Metalloproteinase
  • Pentosan polysulfate
  • Tissue inhibitor of metalloprotease

ASJC Scopus subject areas

  • Immunology
  • Rheumatology
  • Medicine(all)


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