Carotid intima-media thickness progression to predict cardiovascular events in the general population (the PROG-IMT collaborative project): A meta-analysis of individual participant data

Matthias W. Lorenz, Joseph F. Polak, Maryam Kavousi, Ellisiv B. Mathiesen, Henry Völzke, Tomi Pekka Tuomainen, Dirk Sander, Matthieu Plichart, Alberico L. Catapano, Christine M. Robertson, Stefan Kiechl, Tatjana Rundek, Moïse Desvarieux, Lars Lind, Caroline Schmid, Pronabesh DasMahapatra, Lu Gao, Kathrin Ziegelbauer, Michiel L. Bots, Simon G. Thompson

Research output: Contribution to journalArticle

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Abstract

Background Carotid intima-media thickness (cIMT) is related to the risk of cardiovascular events in the general population. An association between changes in cIMT and cardiovascular risk is frequently assumed but has rarely been reported. Our aim was to test this association. Methods We identifi ed general population studies that assessed cIMT at least twice and followed up participants for myocardial infarction, stroke, or death. The study teams collaborated in an individual participant data meta-analysis. Excluding individuals with previous myocardial infarction or stroke, we assessed the association between cIMT progression and the risk of cardiovascular events (myocardial infarction, stroke, vascular death, or a combination of these) for each study with Cox regression. The log hazard ratios (HRs) per SD diff erence were pooled by random eff ects meta-analysis. Findings Of 21 eligible studies, 16 with 36 984 participants were included. During a mean follow-up of 7•0 years, 1519 myocardial infarctions, 1339 strokes, and 2028 combined endpoints (myocardial infarction, stroke, vascular death) occurred. Yearly cIMT progression was derived from two ultrasound visits 2-7 years (median 4 years) apart. For mean common carotid artery intima-media thickness progression, the overall HR of the combined endpoint was 0•97 (95% CI 0•94-1•00) when adjusted for age, sex, and mean common carotid artery intima-media thickness, and 0•98 (0•95-1•01) when also adjusted for vascular risk factors. Although we detected no associations with cIMT progression in sensitivity analyses, the mean cIMT of the two ultrasound scans was positively and robustly associated with cardiovascular risk (HR for the combined endpoint 1•16, 95% CI 1•10-1•22, adjusted for age, sex, mean common carotid artery intima-media thickness progression, and vascular risk factors). In three studies including 3439 participants who had four ultrasound scans, cIMT progression did not correlate between occassions (reproducibility correlations between r=-0•06 and r=-0•02). Interpretation The association between cIMT progression assessed from two ultrasound scans and cardiovascular risk in the general population remains unproven. No conclusion can be derived for the use of cIMT progression as a surrogate in clinical trials. Funding Deutsche Forschungsgemeinschaft.

Original languageEnglish
Pages (from-to)2053-2062
Number of pages10
JournalThe Lancet
Volume379
Issue number9831
DOIs
StatePublished - May 1 2012

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Carotid Intima-Media Thickness
Meta-Analysis
Population
Stroke
Myocardial Infarction
Common Carotid Artery
Blood Vessels

ASJC Scopus subject areas

  • Medicine(all)

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Carotid intima-media thickness progression to predict cardiovascular events in the general population (the PROG-IMT collaborative project) : A meta-analysis of individual participant data. / Lorenz, Matthias W.; Polak, Joseph F.; Kavousi, Maryam; Mathiesen, Ellisiv B.; Völzke, Henry; Tuomainen, Tomi Pekka; Sander, Dirk; Plichart, Matthieu; Catapano, Alberico L.; Robertson, Christine M.; Kiechl, Stefan; Rundek, Tatjana; Desvarieux, Moïse; Lind, Lars; Schmid, Caroline; DasMahapatra, Pronabesh; Gao, Lu; Ziegelbauer, Kathrin; Bots, Michiel L.; Thompson, Simon G.

In: The Lancet, Vol. 379, No. 9831, 01.05.2012, p. 2053-2062.

Research output: Contribution to journalArticle

Lorenz, MW, Polak, JF, Kavousi, M, Mathiesen, EB, Völzke, H, Tuomainen, TP, Sander, D, Plichart, M, Catapano, AL, Robertson, CM, Kiechl, S, Rundek, T, Desvarieux, M, Lind, L, Schmid, C, DasMahapatra, P, Gao, L, Ziegelbauer, K, Bots, ML & Thompson, SG 2012, 'Carotid intima-media thickness progression to predict cardiovascular events in the general population (the PROG-IMT collaborative project): A meta-analysis of individual participant data', The Lancet, vol. 379, no. 9831, pp. 2053-2062. https://doi.org/10.1016/S0140-6736(12)60441-3
Lorenz, Matthias W. ; Polak, Joseph F. ; Kavousi, Maryam ; Mathiesen, Ellisiv B. ; Völzke, Henry ; Tuomainen, Tomi Pekka ; Sander, Dirk ; Plichart, Matthieu ; Catapano, Alberico L. ; Robertson, Christine M. ; Kiechl, Stefan ; Rundek, Tatjana ; Desvarieux, Moïse ; Lind, Lars ; Schmid, Caroline ; DasMahapatra, Pronabesh ; Gao, Lu ; Ziegelbauer, Kathrin ; Bots, Michiel L. ; Thompson, Simon G. / Carotid intima-media thickness progression to predict cardiovascular events in the general population (the PROG-IMT collaborative project) : A meta-analysis of individual participant data. In: The Lancet. 2012 ; Vol. 379, No. 9831. pp. 2053-2062.
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abstract = "Background Carotid intima-media thickness (cIMT) is related to the risk of cardiovascular events in the general population. An association between changes in cIMT and cardiovascular risk is frequently assumed but has rarely been reported. Our aim was to test this association. Methods We identifi ed general population studies that assessed cIMT at least twice and followed up participants for myocardial infarction, stroke, or death. The study teams collaborated in an individual participant data meta-analysis. Excluding individuals with previous myocardial infarction or stroke, we assessed the association between cIMT progression and the risk of cardiovascular events (myocardial infarction, stroke, vascular death, or a combination of these) for each study with Cox regression. The log hazard ratios (HRs) per SD diff erence were pooled by random eff ects meta-analysis. Findings Of 21 eligible studies, 16 with 36 984 participants were included. During a mean follow-up of 7•0 years, 1519 myocardial infarctions, 1339 strokes, and 2028 combined endpoints (myocardial infarction, stroke, vascular death) occurred. Yearly cIMT progression was derived from two ultrasound visits 2-7 years (median 4 years) apart. For mean common carotid artery intima-media thickness progression, the overall HR of the combined endpoint was 0•97 (95{\%} CI 0•94-1•00) when adjusted for age, sex, and mean common carotid artery intima-media thickness, and 0•98 (0•95-1•01) when also adjusted for vascular risk factors. Although we detected no associations with cIMT progression in sensitivity analyses, the mean cIMT of the two ultrasound scans was positively and robustly associated with cardiovascular risk (HR for the combined endpoint 1•16, 95{\%} CI 1•10-1•22, adjusted for age, sex, mean common carotid artery intima-media thickness progression, and vascular risk factors). In three studies including 3439 participants who had four ultrasound scans, cIMT progression did not correlate between occassions (reproducibility correlations between r=-0•06 and r=-0•02). Interpretation The association between cIMT progression assessed from two ultrasound scans and cardiovascular risk in the general population remains unproven. No conclusion can be derived for the use of cIMT progression as a surrogate in clinical trials. Funding Deutsche Forschungsgemeinschaft.",
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T1 - Carotid intima-media thickness progression to predict cardiovascular events in the general population (the PROG-IMT collaborative project)

T2 - A meta-analysis of individual participant data

AU - Lorenz, Matthias W.

AU - Polak, Joseph F.

AU - Kavousi, Maryam

AU - Mathiesen, Ellisiv B.

AU - Völzke, Henry

AU - Tuomainen, Tomi Pekka

AU - Sander, Dirk

AU - Plichart, Matthieu

AU - Catapano, Alberico L.

AU - Robertson, Christine M.

AU - Kiechl, Stefan

AU - Rundek, Tatjana

AU - Desvarieux, Moïse

AU - Lind, Lars

AU - Schmid, Caroline

AU - DasMahapatra, Pronabesh

AU - Gao, Lu

AU - Ziegelbauer, Kathrin

AU - Bots, Michiel L.

AU - Thompson, Simon G.

PY - 2012/5/1

Y1 - 2012/5/1

N2 - Background Carotid intima-media thickness (cIMT) is related to the risk of cardiovascular events in the general population. An association between changes in cIMT and cardiovascular risk is frequently assumed but has rarely been reported. Our aim was to test this association. Methods We identifi ed general population studies that assessed cIMT at least twice and followed up participants for myocardial infarction, stroke, or death. The study teams collaborated in an individual participant data meta-analysis. Excluding individuals with previous myocardial infarction or stroke, we assessed the association between cIMT progression and the risk of cardiovascular events (myocardial infarction, stroke, vascular death, or a combination of these) for each study with Cox regression. The log hazard ratios (HRs) per SD diff erence were pooled by random eff ects meta-analysis. Findings Of 21 eligible studies, 16 with 36 984 participants were included. During a mean follow-up of 7•0 years, 1519 myocardial infarctions, 1339 strokes, and 2028 combined endpoints (myocardial infarction, stroke, vascular death) occurred. Yearly cIMT progression was derived from two ultrasound visits 2-7 years (median 4 years) apart. For mean common carotid artery intima-media thickness progression, the overall HR of the combined endpoint was 0•97 (95% CI 0•94-1•00) when adjusted for age, sex, and mean common carotid artery intima-media thickness, and 0•98 (0•95-1•01) when also adjusted for vascular risk factors. Although we detected no associations with cIMT progression in sensitivity analyses, the mean cIMT of the two ultrasound scans was positively and robustly associated with cardiovascular risk (HR for the combined endpoint 1•16, 95% CI 1•10-1•22, adjusted for age, sex, mean common carotid artery intima-media thickness progression, and vascular risk factors). In three studies including 3439 participants who had four ultrasound scans, cIMT progression did not correlate between occassions (reproducibility correlations between r=-0•06 and r=-0•02). Interpretation The association between cIMT progression assessed from two ultrasound scans and cardiovascular risk in the general population remains unproven. No conclusion can be derived for the use of cIMT progression as a surrogate in clinical trials. Funding Deutsche Forschungsgemeinschaft.

AB - Background Carotid intima-media thickness (cIMT) is related to the risk of cardiovascular events in the general population. An association between changes in cIMT and cardiovascular risk is frequently assumed but has rarely been reported. Our aim was to test this association. Methods We identifi ed general population studies that assessed cIMT at least twice and followed up participants for myocardial infarction, stroke, or death. The study teams collaborated in an individual participant data meta-analysis. Excluding individuals with previous myocardial infarction or stroke, we assessed the association between cIMT progression and the risk of cardiovascular events (myocardial infarction, stroke, vascular death, or a combination of these) for each study with Cox regression. The log hazard ratios (HRs) per SD diff erence were pooled by random eff ects meta-analysis. Findings Of 21 eligible studies, 16 with 36 984 participants were included. During a mean follow-up of 7•0 years, 1519 myocardial infarctions, 1339 strokes, and 2028 combined endpoints (myocardial infarction, stroke, vascular death) occurred. Yearly cIMT progression was derived from two ultrasound visits 2-7 years (median 4 years) apart. For mean common carotid artery intima-media thickness progression, the overall HR of the combined endpoint was 0•97 (95% CI 0•94-1•00) when adjusted for age, sex, and mean common carotid artery intima-media thickness, and 0•98 (0•95-1•01) when also adjusted for vascular risk factors. Although we detected no associations with cIMT progression in sensitivity analyses, the mean cIMT of the two ultrasound scans was positively and robustly associated with cardiovascular risk (HR for the combined endpoint 1•16, 95% CI 1•10-1•22, adjusted for age, sex, mean common carotid artery intima-media thickness progression, and vascular risk factors). In three studies including 3439 participants who had four ultrasound scans, cIMT progression did not correlate between occassions (reproducibility correlations between r=-0•06 and r=-0•02). Interpretation The association between cIMT progression assessed from two ultrasound scans and cardiovascular risk in the general population remains unproven. No conclusion can be derived for the use of cIMT progression as a surrogate in clinical trials. Funding Deutsche Forschungsgemeinschaft.

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