Cardiovascular responses of rabbits to ESB: Effects of anesthetization, stimulus frequency and pulse-train duration

James S. Francis, Larry D. Sampson, Terry Gerace, Neil Schneiderman

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Chronically prepared rabbits received short (1.0 sec) or long (10 sec) pulse-trains of electrical stimulation in septal region or hypothalamus. One sec trains of 50-, 100-, and 200-pulse pairs per sec (p.p.p.s.) elicited equivalent cardiovascular responses (i.e., an increase in mean systemic arterial blood pressure accompanied by bradycardia) provided current-intensity was increased as pulse-frequency was decreased; whereas, cardiovascular responses were attenuated or abolished by 12-25 p.p.p.s. stimulation. Anesthetization (25 mg/kg sodium pentobarbital) attenuated cardiovascular responses to stimulation and converted the pressor increase elicited by the 1.0 sec pulse-train into a depressor response. In contrast to the single cardiovascular pattern elicited by the 1.0 sec train at all electrode sites, several cardiovascular patterns were obtained by stimulating different sites in unanesthetized rabbits with a 10 sec train. The differences in result following stimulation with 1.0 and 10 sec pulse-trains were discussed in terms of (a) higher current-intensity required to elicit cardiovascular responses with a 1.0 sec train, and (b) possible modulation of baroreceptor responses occurring during the longer train.

Original languageEnglish (US)
Pages (from-to)195-203
Number of pages9
JournalPhysiology AND Behavior
Volume11
Issue number2
DOIs
StatePublished - Aug 1973

Keywords

  • Blood pressure
  • Heart rate
  • Hypothalamus
  • Intracranial stimulation
  • Rabbit
  • Septal region

ASJC Scopus subject areas

  • Physiology (medical)
  • Behavioral Neuroscience

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